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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Effect of APOE ε4 genotype on amyloid-β and tau accumulation in Alzheimer’s disease

Fig. 4

Comparison of annual changes in 18F-florbetaben and 18F-flortaucipir SUVR between the ApoE ε4− and ε4+ groups. a VOI-based comparison between the ApoE ε4− and ε4+ groups. Data are presented as means (dots) and standard deviations (error bars) of the ε4− (blue) and ε4+ (red) groups. P values for the comparison between the ε4− and ε4+ groups are expressed as -Log10P. Red bars represent the regions that survived correcting for region-wise multiple comparisons (false discovery rate-corrected P < 0.05), and blue dotted lines represent uncorrected P = 0.05. b Surface-based comparisons between the ApoE ε4− and ε4+ groups. Regions surrounded by white lines (ε4− < ε4+ in Aβ and tau accumulation rates in all individuals, and ε4− < ε4+ in tau accumulation rate in Aβ+ individuals) represent the cortical areas that survived correcting for multiple comparisons (false discovery rate-corrected P < 0.05). P values for the comparison between the ε4− and ε4+ groups are expressed as -Log10P. P values for the comparison between the baseline and follow-up are expressed as -Log10P. Aβ±, Aβ-positivity; ApoE, apolipoprotein E; SUVR, standardized uptake value ratio; A, 18F-florbetaben; T, 18F-flortaucipir

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