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Table 2 Estimated mean difference in 6- and 12-month change from baseline on brain glucose metabolism for the active groups compared to the control group

From: The impact of a multi-domain intervention on cerebral glucose metabolism: analysis from the randomized ancillary FDG PET MAPT trial

Groups

n

Estimated mean within-group change from baseline (95% CI)

Estimated mean between-group difference in change from baseline (95%CI)

Vs control

p

Adjusted p*

Primary analysis

Effect of MI

At 6 months

MI plus placebo or omega-3

34

0.008 (− 0.011; 0.027)

0.004 (− 0.022; 0.030)

0.752

0.901

No MI plus placebo or omega-3

33

0.004 (− 0.014; 0.022)

Secondary analysis

Effect of MI at 12 months

MI plus placebo or omega-3

34

0.016 (− 0.022; 0.055)

0.008 (− 0.044; 0.061)

0.752

0.901

No MI plus placebo or omega-3

33

0.008 (− 0.027; 0.044)

Effect of omega-3 at 6 months

Omega-3 plus MI or no MI

38

0.009 (− 0.009; 0.026)

0.007 (− 0.019; 0.033)

0.612

0.352

No omega-3 plus MI or no MI

29

0.002 (−0.018; 0.022)

Effect of omega-3 at 12 months

Omega-3 plus MI or no MI

38

0.018 (− 0.017; 0.052)

0.013 (− 0.039; 0.066)

0.612

0.352

No omega-3 plus MI or no MI

29

0.004 (− 0.035; 0.043)

Exploratory analysis

Effect of MI, omega-3, and combination of both at 6 months

MI plus omega-3

20

0.008 (− 0.017; 0.033)

0.010 (− 0.026; 0.047)

0.572

0.552

Omega-3 only

18

0.009 (− 0.015; 0.033)

0.012 (− 0.024; 0.047)

0.524

0.236

MI only

14

0.008 (− 0.021; 0.038)

0.010 (− 0.029; 0.050)

0.603

0.637

Placebo

15

− 0.002 (− 0.028; 0.024)

Effect of MI, omega-3, and combination of both at 12 months

MI plus omega-3

20

0.017 (− 0.034; 0.067)

0.021 (− 0.052; 0.093)

0.572

0.552

Omega-3 only

18

0.019 (− 0.030; 0.067)

0.023 (− 0.048; 0.094)

0.524

0.236

MI only

14

0.017 (− 0.042; 0.075)

0.021 (− 0.058; 0.100)

0.603

0.637

Placebo

15

− 0.004 (− 0.057; 0.048)

  1. *Analysis adjusted for age, sex, level of education, APO ε4 genotype, clinical dementia rating global score, and group intervention
  2. Abbreviation: MI multidomain intervention