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Table 3 Association of cerebrospinal fluid (CSF) level of metabolites with p-tau levels in CSF

From: Association of lysophosphatidic acids with cerebrospinal fluid biomarkers and progression to Alzheimer’s disease

 

ACE cohort

Heidelberg/Mannheim cohort

Meta-analysis

β

SE

P value

β

SE

P value

β

SE

Direction

P value

FDR

LPA C20:1

0.350

0.086

8.16 × 10−5

0.333

0.174

6.42 × 10−2

0.347

0.077

++

7.11 × 10−6

8.25 × 10−5

Isomer-LPA C22:5

0.302

0.082

3.15 × 10−4

0.438

0.170

1.46 × 10−2

0.328

0.074

++

8.68 × 10−6

8.25 × 10−5

LPA C22:6

0.279

0.083

9.39 × 10−4

0.214

0.198

2.88 × 10−1

0.270

0.076

++

4.03 × 10−4

2.55 × 10−3

LPA C16:0

0.218

0.080

7.67 × 10−3

0.316

0.214

1.48 × 10−1

0.230

0.075

++

2.26 × 10−3

1.07 × 10−2

LPA C16:1

0.226

0.086

9.49 × 10−3

0.112

0.182

5.43 × 10−1

0.206

0.078

++

8.23 × 10−3

3.13 × 10−2

LPA C22:4

0.168

0.082

4.17 × 10−2

0.287

0.196

1.53 × 10−1

0.186

0.076

++

1.39 × 10−2

4.40 × 10−2

LPA C18:1

0.217

0.099

3.08 × 10−2

0.171

0.212

4.25 × 10−1

0.209

0.090

++

2.04 × 10−2

5.54 × 10−2

aLPA C18:1

0.110

0.128

3.91 × 10−1

0.425

0.169

1.69 × 10−2

0.224

0.102

++

2.79 × 10−2

6.62 × 10−2

cLPA C18:0

0.159

0.089

7.53 × 10−2

0.243

0.197

2.26 × 10−1

0.173

0.081

++

3.23 × 10−2

6.82 × 10−2

LPA C20:3

0.072

0.101

4.79 × 10−1

0.380

0.163

2.62 × 10−2

0.157

0.086

++

6.77 × 10−2

1.29 × 10−1

cLPA C18:1

0.115

0.092

2.14 × 10−1

0.265

0.189

1.69 × 10−1

0.144

0.083

++

8.25 × 10−2

1.42 × 10−1

LPA C14:0

0.129

0.091

1.60 × 10−1

0.088

0.187

6.42 × 10−1

0.121

0.082

++

1.40 × 10–1

2.12 × 10−1

LPA C22:5

0.065

0.087

4.56 × 10−1

0.326

0.184

8.51 × 10−2

0.112

0.078

++

1.52 × 10−1

2.12 × 10−1

aLPA C16:1

0.061

0.131

6.42 × 10−1

0.287

0.168

9.65 × 10−2

0.146

0.103

++

1.56 × 10−1

2.12 × 10−1

LPA C18:0

0.096

0.089

2.82 × 10−1

0.077

0.188

6.86 × 10−1

0.092

0.080

++

2.50 × 10−1

3.16 × 10−1

LPA C18:2

− 0.094

0.083

2.60 × 10−1

−0.024

0.175

8.90 × 10−1

− 0.081

0.075

2.79 × 10−1

3.30 × 10−1

cLPA C16:0

0.102

0.104

3.28 × 10−1

0.075

0.196

7.04 × 10−1

0.096

0.092

++

2.95 × 10−1

3.30 × 10−1

LPA C20:4

0.077

0.095

4.20 × 10−1

0.081

0.176

6.49 × 10−1

0.078

0.084

++

3.53 × 10−1

3.72 × 10−1

LPA C20:5

− 0.028

0.088

7.54 × 10−1

0.114

0.193

5.59 × 10−1

− 0.003

0.081

−+

9.68 × 10−1

9.68 × 10−1

  1. Direction column indicates the direction of regression coefficient of association in the ACE and Heidelberg/Mannheim cohort respectively
  2. Abbreviations: LPA lysophosphatidic acid, cLPA cyclic lysophosphatidic acid, aLPA alkyl-Lysophosphatidic acid, SE standard error, FDR false discovery rate