(A) | Total WMH | (B) | Total WMH |
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Model 1 | Model 2 | Model 1 | Model 2 |
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β | p | β | p | R2 | β | p | β | p | R2 |
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Age | 0.47 | < 0.001 | 0.35 | 0.01 | 0.32 | Age | 0.53 | < 0.001 | 0.42 | 0.01 | 0.26 |
Sex | − 0.05 | 0.72 | – | – | Sex | − 0.03 | 0.89 | – | – |
SBP | 0.24 | 0.02 | 0.01 | 0.96 | SBP | 0.35 | 0.02 | 0.10 | 0.51 |
DBP | 0.37 | < 0.001 | 0.23 | 0.10 | DBP | 0.19 | 0.19 | – | – |
HbA1C | 0.20 | 0.06 | – | – | HbA1C | 0.39 | 0.01 | 0.20 | 0.17 |
Aβ | 0.24 | 0.05 | 0.09 | 0.39 | Aβ | − 0.23 | 0.14 | – | – |
- Standardized betas (β) and p values are reported from regression models where total WMH (log-transformed) are regressed onto age, sex, SBP, DBP, HbA1C, and Aβ controlling for TIV (model 1), or for TIV and significant covariates (model 2) in young/middle-aged adults (A; N = 86, mean age 37.41 ± 12.85) and in older adults (B, N = 51, mean age 71.20 ± 6.26). Adjusted R2 were indicated for model 2. Significant p values (< 0.05) are in bold
- For young/middle-aged adults, analyses were performed with 86 participants for age and sex, 85 participants for SBP and DBP, 80 participants for HbA1C, and 65 participants for Aβ in model 1 and with 65 participants in model 2. For older adults, analyses were performed with 51 participants for age and sex; 48 participants for SBP, DBP, and HbA1C; and 44 participants for Aβ in model 1 and with 45 participants in model 2
- SBP systolic blood pressure, DBP diastolic blood pressure, HbA1C glycated hemoglobin, Aβ cortical β-amyloid, TIV total intracranial volume