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Table 3 Relationships between total WMH, age, vascular risk factors, and Aβ in the subgroup of young/middle-aged adults (A) and in the subgroup of older adults (B)

From: White matter hyperintensities across the adult lifespan: relation to age, Aβ load, and cognition

(A)

Total WMH

(B)

Total WMH

Model 1

Model 2

Model 1

Model 2

β

p

β

p

R2

β

p

β

p

R2

Age

0.47

< 0.001

0.35

0.01

0.32

Age

0.53

< 0.001

0.42

0.01

0.26

Sex

− 0.05

0.72

Sex

− 0.03

0.89

SBP

0.24

0.02

0.01

0.96

SBP

0.35

0.02

0.10

0.51

DBP

0.37

< 0.001

0.23

0.10

DBP

0.19

0.19

HbA1C

0.20

0.06

HbA1C

0.39

0.01

0.20

0.17

0.24

0.05

0.09

0.39

− 0.23

0.14

  1. Standardized betas (β) and p values are reported from regression models where total WMH (log-transformed) are regressed onto age, sex, SBP, DBP, HbA1C, and Aβ controlling for TIV (model 1), or for TIV and significant covariates (model 2) in young/middle-aged adults (A; N = 86, mean age 37.41 ± 12.85) and in older adults (B, N = 51, mean age 71.20 ± 6.26). Adjusted R2 were indicated for model 2. Significant p values (< 0.05) are in bold
  2. For young/middle-aged adults, analyses were performed with 86 participants for age and sex, 85 participants for SBP and DBP, 80 participants for HbA1C, and 65 participants for Aβ in model 1 and with 65 participants in model 2. For older adults, analyses were performed with 51 participants for age and sex; 48 participants for SBP, DBP, and HbA1C; and 44 participants for Aβ in model 1 and with 45 participants in model 2
  3. SBP systolic blood pressure, DBP diastolic blood pressure, HbA1C glycated hemoglobin, cortical β-amyloid, TIV total intracranial volume