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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: The two faces of synaptic failure in AppNL-G-F knock-in mice

Fig. 3

Deficits in hippocampal synaptic plasticity in AppNL-G-F mice at 6–8 months of age. a Basal synaptic transmission as measured by input/output curves did not differ significantly between genotypes. b Paired-pulse ratio was decreased at the 10-ms interpulse interval in AppNL-G-F mice compared to AppNL controls (t = 2.102, p = 0.0484 Welch test). c Slices from AppNL-G-F developed a smaller initial amplitude than APP NL controls and displayed impaired maintenance of potentiation resulting in a significant difference to AppNL littermates (F1, 12 = 12.17, p = 0.0045, RM-ANOVA). d LFS-induced LTD was not affected by Aß-mediated pathology in AppNL-G-F mice. Data are shown as mean ± SEM. Asterisks indicate difference in fEPSPs between AppNL and AppNL-G-F: *p < 0.05, **p < 0.01. Insets depict representative analogue traces, taken during baseline recording (solid line), after TBS (broken line), and at the end of recording (240 min, dotted line)

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