Fig. 4From: Normalization of CSF pTau measurement by Aβ40 improves its performance as a biomarker of Alzheimer’s diseaseCross-sectional associations between Aβ PET, CSF pTau/Aβ40, and tau PET. Associations between baseline Aβ PET and a CSF pTau, b CSF pTau/Aβ40, and c temporal tau PET. Associations between baseline CSF pTau and CSF pTau/Aβ40 in the whole cohort (d), Aβ− (e), and Aβ+ (f) participants. Associations between baseline CSF pTau/Aβ40 and Temporal-metaROI tau PET in the whole cohort (g), Aβ− (h), and Aβ+ (i) participants. The vertical and horizontal gray dashed lines reflect the abnormal thresholds of corresponding biomarkers in the x-axis and y-axis respectively. Abbreviations: Aβ = amyloid-β; A = Aβ PET; − = negative; + = positive; AD = Alzheimer’s disease; CU = cognitively unimpaired; FTP = 18F-flortaucipir; MCI = mild cognitive impairment; pTau = phosphorylated tau; PTAU = CSF pTau or CSF pTau/Aβ40 ratio; SUVR = standardized uptake value ratio; T = CSF pTau or CSF pTau/Aβ40 or tau PETBack to article page