Cardiovascular risk factors indirectly affect acute post-stroke cognition through stroke severity and prior cognitive impairment: a moderated mediation analysis

Table 3 Indirect associations between predictors and cognitive performance

	Effects mediated through stroke severity (NIHSS)		Effects mediated through prior dementia
	Unstandardised coefficient	95% bias-corrected CI	Unstandardised coefficient	95% bias-corrected CI
Age	− 0.009*	− 0.015 to − 0.003	− 0.043*	− 0.069 to − 0.024
Sex (female)	0.023	− 0.145–0.172	0.071	− 0.186–0.349
Previous stroke	− 0.006	− 0.175–0.168	− 0.387*	− 0.753 to − 0.130
Previous TIA	0.383*	0.083–0.745	0.247	− 0.218–2.152
Atrial fibrillation	− 0.266*	− 0.493 to − 0.052	− 0.105	− 0.479–0.202
Diabetes	0.019	− 0.161–0.207	0.020	− 0.398–0.516
Hypertension	− 0.057	− 0.244–0.109	0.096	− 0.278–0.476
Vascular disease	− 0.002	− 0.297–0.322	− 0.440	− 0.981–0.064
Vascular disease × diabetes	− 0.349	− 0.748–0.030	–	–
Vascular disease × hypertension	0.363	− 0.032–0.759	–	–

TIA transient ischaemic attack, NIHSS National Institutes of Health Stroke Scale
*Significant at p < 0.05

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