Cardiovascular risk factors indirectly affect acute post-stroke cognition through stroke severity and prior cognitive impairment: a moderated mediation analysis

Table 2 Direct associations between predictors and stroke severity, dementia, and cognitive performance

	Stroke severity (NIHSS)		Prior dementia		Cognitive performance
	Unstandardised coefficient	95% bias-corrected CI	Unstandardised coefficient	95% bias-corrected CI	Unstandardised coefficient	95% bias-corrected CI
Age	0.012*	0.004–0.019	0.059*	0.039–0.078	0.003	− 0.016–0.027
Sex (female)	− 0.031	− 0.210–0.180	− 0.098	− 0.458–0.248	− 0.264	− 0.588–0.046
Previous stroke	0.008	− 0.217–0.222	0.538*	0.176–0.932	0.230	− 0.129–0.649
Previous TIA	− 0.512*	− 0.934 to − 0.147	− 0.342	− 3.886–0.279	− 0.141	− 2.136–0.510
Atrial fibrillation	0.355*	0.075–0.609	0.145	− 0.270–0.554	− 0.092	− 0.464–0.279
Diabetes	− 0.025	− 0.274–0.209	− 0.028	− 0.636–0.535	− 0.041	− 0.604–0.508
Hypertension	0.076	− 0.146–0.301	− 0.133	− 0.571–0.377	− 0.065	− 0.502–0.364
Vascular disease	0.002	− 0.405–0.374	0.611	− 0.051–1.246	0.390	− 0.178–1.127
Vascular disease × diabetes	0.466	− 0.031–0.924	–	–	–	–
Vascular disease × hypertension	− 0.486	− 0.971–0.016	–	–	–	–

TIA transient ischaemic attack, NIHSS National Institutes of Health Stroke Scale
*Significant at p < 0.05

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