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Table 3 Categorization according to clinical diagnosis and ATN biomarker profiles

From: CSF total tau/α-synuclein ratio improved the diagnostic performance for Alzheimer’s disease as an indicator of tau phosphorylation

ATN profiles

EOAD

LOAD

MCI

SCD

PD

HC

N/αS+ (%)

 

A−T−N−

N/αS−

1

4

5

8

34

27

5

N/αS+

3

1

 

A+T−N−

N/αS−

3

1

1

4

59

N/αS+

8

3

2

AD

A+T+N−

N/αS−

1

0

N/αS+

A+T+N+

N/αS−

2

1

1

1

92

N/αS+

41

17

2

1

 

A+T−N+

N/αS−

100

N/αS+

10

5

1

SNAP

A−T−N+

N/αS−

1

1

1

0

N/αS+

A−T+N−

N/αS−

1

1

1

1

0

N/αS+

A−T+N+

N/αS-

1

2

2

2

2

40

N/αS+

5

1

N/αS+ (%)

90

77

18

24

7

3

 
  1. Abbreviations: AD Alzheimer’s disease, EOAD early-onset Alzheimer’s disease, LOAD late-onset Alzheimer’s disease, MCI mild cognitive impairment, SCD subjective cognitive decline, PD Parkinson’s disease, HC healthy control, SNAP suspected non-Alzheimer’s disease pathophysiology