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Table 3 Categorization according to clinical diagnosis and ATN biomarker profiles

From: CSF total tau/α-synuclein ratio improved the diagnostic performance for Alzheimer’s disease as an indicator of tau phosphorylation

ATN profiles EOAD LOAD MCI SCD PD HC N/αS+ (%)
  A−T−N− N/αS− 1 4 5 8 34 27 5
N/αS+ 3 1
  A+T−N− N/αS− 3 1 1 4 59
N/αS+ 8 3 2
AD A+T+N− N/αS− 1 0
N/αS+
A+T+N+ N/αS− 2 1 1 1 92
N/αS+ 41 17 2 1
  A+T−N+ N/αS− 100
N/αS+ 10 5 1
SNAP A−T−N+ N/αS− 1 1 1 0
N/αS+
A−T+N− N/αS− 1 1 1 1 0
N/αS+
A−T+N+ N/αS- 1 2 2 2 2 40
N/αS+ 5 1
N/αS+ (%) 90 77 18 24 7 3  
  1. Abbreviations: AD Alzheimer’s disease, EOAD early-onset Alzheimer’s disease, LOAD late-onset Alzheimer’s disease, MCI mild cognitive impairment, SCD subjective cognitive decline, PD Parkinson’s disease, HC healthy control, SNAP suspected non-Alzheimer’s disease pathophysiology
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