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Table 2 Analysis of ROC curve for each biomarker between EOAD, LOAD versus PD, and HC

From: CSF total tau/α-synuclein ratio improved the diagnostic performance for Alzheimer’s disease as an indicator of tau phosphorylation

CSF biomarker Cutoff AUC 95% CI Sensitivity (%) Specificity (%)
42 555.4a 0.899 0.846–0.939 90 81
T-tau 318.9a 0.908 0.857–0.946 81 91
P-tau181 57.6a 0.860 0.801–0.907 67 90
42/P-tau181 10.6 0.948 0.905–0.976 92 90
T-tau/α-syn 0.412 0.930 0.883–0.962 89 95
P-tau181/α-syn 0.071 0.869 0.811–0.914 80 82
42/P-tau181, T-tau/α-syn 21.5 0.956 0.915–0.981 96 87
  1. Abbreviation: ROC receiver operator characteristic, EOAD early-onset Alzheimer’s disease, LOAD late-onset Alzheimer’s disease, PD Parkinson’s disease, HC healthy control, CSF cerebrospinal fluid, AUC area under the curve, 42 amyloid-β 1-42, T-tau total tau, P-tau181 phosphorylated tau 181, α-syn α-synuclein
  2. aUnit: pg/mL
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