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Table 3 EOnonAD and LOnonAD demographic comparisons to CN. The comparisons were done using ANOVA and chi-square tests with two-sided p values. The Bonferroni-corrected pairwise differences relative to CN are discussed in the “Results” section. Significant p values (< 0.05) are bolded

From: Neurodegenerative changes in early- and late-onset cognitive impairment with and without brain amyloidosis

Variable

CN (N = 291)

EOnonADMCI (N = 113)

EOnonADDEM (N = 8)

p value

LOnonADMCI (N = 151)

LOnonADDEM(N = 24)

p value

Age, years, mean (SD)

74.3 (6.4)

65.5 (5.8)

66.3 (5.8)

< 0.001

77.6 (6.2)

79.4 (5.8)

< 0.001

Sex, male %

52.2

50.4

50.0

0.944

59.6*

83.3*

0.008

Education, years, mean (SD)

16.7 (2.6)

16.2 (2.5)

15.6 (3.5)

0.095

16.3 (2.5)

15.6 (3.0)

0.037

%APOEε4, 0/1/2 alleles

77/22/1

68/30/2

71/14/14

0.028

86/13/2

83/13/4

0.173

Global CDR, mean (SD)

0.02 (0.09)

0.46 (0.17)***

0.69 (0.26)***

< 0.001

0.48 (0.11)***

0.83 (0.24)***

< 0.001

MMSE, mean (SD)

29.0 (1.3)

28.6 (1.5)***

23.0 (2.4)***

< 0.001

28.4 (1.6)***

23.6 (1.9)***

< 0.001

Global cortical [18F]-florbetapir SUVR, mean (SD)

1.03 (0.06)

1.03 (0.08)

1.04 (0.08)

0.214

1.01 (0.09)

1.01 (0.10)

0.160

Change in cortical [18F]-florbetapir SUVR referenced to CN (pvalue)

ref

− 0.0049 (0.1835)*

− 0.0387 (0.0175)*

N/A

− 0.0099 (0.0091)

0.0093 (0.5425)

N/A

Tau scans,N

126

38

3

N/A

51

2

N/A

  1. *MCI and DEM significantly different at p < 0.05
  2. ***MCI and DEM significantly different at p < 0.001