Variable | CN (N = 291) | EOnonADMCI (N = 113) | EOnonADDEM (N = 8) | p value | LOnonADMCI (N = 151) | LOnonADDEM(N = 24) | p value |
---|---|---|---|---|---|---|---|
Age, years, mean (SD) | 74.3 (6.4) | 65.5 (5.8) | 66.3 (5.8) | < 0.001 | 77.6 (6.2) | 79.4 (5.8) | < 0.001 |
Sex, male % | 52.2 | 50.4 | 50.0 | 0.944 | 59.6* | 83.3* | 0.008 |
Education, years, mean (SD) | 16.7 (2.6) | 16.2 (2.5) | 15.6 (3.5) | 0.095 | 16.3 (2.5) | 15.6 (3.0) | 0.037 |
%APOEε4, 0/1/2 alleles | 77/22/1 | 68/30/2 | 71/14/14 | 0.028 | 86/13/2 | 83/13/4 | 0.173 |
Global CDR, mean (SD) | 0.02 (0.09) | 0.46 (0.17)*** | 0.69 (0.26)*** | < 0.001 | 0.48 (0.11)*** | 0.83 (0.24)*** | < 0.001 |
MMSE, mean (SD) | 29.0 (1.3) | 28.6 (1.5)*** | 23.0 (2.4)*** | < 0.001 | 28.4 (1.6)*** | 23.6 (1.9)*** | < 0.001 |
Global cortical [18F]-florbetapir SUVR, mean (SD) | 1.03 (0.06) | 1.03 (0.08) | 1.04 (0.08) | 0.214 | 1.01 (0.09) | 1.01 (0.10) | 0.160 |
Change in cortical [18F]-florbetapir SUVR referenced to CN (pvalue) | ref | − 0.0049 (0.1835)* | − 0.0387 (0.0175)* | N/A | − 0.0099 (0.0091) | 0.0093 (0.5425) | N/A |
Tau scans,N | 126 | 38 | 3 | N/A | 51 | 2 | N/A |