Table 3 Characteristics of the study sample at baseline. MRI volumetric analyses are corrected for total intracranial volume (TIV) and reported in percent %. Absolute scores of the neuropsychological tests are reported
From: Imaging the aging brain: study design and baseline findings of the SENIOR cohort
| Â | Â | Total |
|---|---|---|
Global information | Number of subjects | 142 |
Female, % | 50 | |
Age in years, mean (SD) | 60 (6.3) | |
Baccalaureate degree or higher education level, % | 83.1 | |
Diabetes or risk, % | 5.9 | |
Hypertension, % | 30.3 | |
Dyslipidemia, % | 27.5 | |
Body mass index, mean (SD) | 25.08 (4.4) | |
Depression, % | 6.3 | |
At least one APOE ε 4 allele for carried, % (analysis from 109 subjects) | 22.9 | |
Neuropsychology | ||
| Â | MMSE score, mean | 29.2 (1.0) |
Memory | Mattis score, mean (SD) | 142.3 (2.8) |
Corsi block-tapping, direct and inverse, mean (SD) | 5.3 (0.9); 4.7 (0.9) | |
Digit span, direct and inverse, mean (SD) | 6 (1.1); 4.7 (1.1) | |
Grober and Buschke, total recall, mean (SD) | 46.6 (1.4) | |
Rey Complex Figure Test, immediate copy score, mean (SD) | 35.0 (1.4) | |
Rey Complex Figure Test, 3-min copy score, mean (SD) | 20.5 (7.4) | |
DMS48, immediate recall, % (SD) | 96.9 (3.7) | |
DMS48, delayed recall, % (SD) | 97.3 (3.1) | |
Executive functions | TMT A, time in seconds, mean (SD) | 31.9 (9.8) |
TMT B, time in seconds, mean (SD) | 72.3 (29.8) | |
Stroop Interference, time in seconds, mean (SD) | 53.8 (11.8) | |
BREF, total, mean (SD) | 17.1 (1.3) | |
Language | Verbal fluency, mean (SD) | 39.0 (9.1) |
Phonematic fluency, mean (SD) | 23.9 (6.7) | |
DO 80 score, mean (SD) | 79.8 (0.7) | |
DO 80 paraphasias, mean (SD) | 0.1 (0.5) | |
Variability | Intra-person across-test variability | 0.89 (0.4) |
MRI Scorings | ||
| Â | Fazekas Score1, mean (SD) | 1.2 (1.1) |
Med. temporal atrophy1 R/L, mean (SD) | 0.33 (0.53); 0.21 (0.46) | |
Enlarged ventricles1, % of subjects | 13.7 | |
Volumetric analyses | Gray matter volume2, mean (SD) | 47.81 (2.04) |
White matter volume2, mean (SD) | 35.59 (2.76) | |
CSF volume2, mean (SD) | 16.61 (3.12) | |
Hippocampal volume2, mean (SD) | 0.56 (0.05) | |
White matter lesions | Total lesion count, mean (SD) | 10.6 (7.1) |
Total lesion volume2, mean (SD) | 8.72×10−4 (12×10−5) | |
Periventricular lesion volume2, mean (SD) | 7.30×10−4 (11×10−5) | |
Juxtacortical lesion volume2, mean (SD) | 9.01×10−5 (1.43×10−4) | |
Deep white lesion volume2, mean (SD) | 5.12×10−5 (1.19×10−4) | |
PET (n = 81) | Index PIB global, mean (SD) | 1.28 (0.15) |
Subjects PIB positive (> 1.45), % | 8.6% | |