Table 1 Proteins more abundant in AD relative to control patients. Proteins in the same amount of 8 control and 8 AD cortical samples were determined by LC/MS/MS, generating spectral count data that reflects the relative amount of protein when two identical proteins are compared. The data are presented as the ratio of the spectral counts in AD divided by the control samples. A Wilcoxon rank-sum t test (on raw values) and a Welch’s t-test (on log-transformed quantile-normalized values) were performed to assess statistical significance between the two groups
From: Diverse proteins aggregate in mild cognitive impairment and Alzheimer’s disease brain
Protein name | Ratio AD/control | Adjusted P value rank t test | Adjusted P value, log/quant t test | Description |
|---|---|---|---|---|
CAMK2G | 34.1 | 0.35284 | 0.36965 | Calcium/calmodulin-dependent protein kinase type II subunit gamma |
VARS | 7.5 | 0.02652 | 0.02652 | Valine-tRNA ligase |
CORO1A | 6.4 | 0.00292 | 0.01072 | Coronin |
UBC | 6.1 | 0.18882 | 0.16372 | Polyubiquitin-C |
APOE | 6 | 0.24853 | 0.25648 | Apolipoprotein E |
CADPS | 5.9 | 0.02406 | 0.02181 | Calcium-dependent secretion activator 1 |
UBB | 5.9 | 0.18882 | 0.16481 | Ubiquitin |
UBA52 | 5.8 | 0.07478 | 0.05029 | Ubiquitin-60S ribosomal protein L40 |
FN1 | 5.5 | 0.27685 | 0.26619 | Fibronectin |
CRMP1 | 5.4 | 0.15919 | 0.15661 | Dihydropyrimidinase-related protein 1 |
GPI | 5.3 | 0.04530 | 0.02897 | Glucose-6-phosphate isomerase |
USP14 | 5.2 | 0.05072 | 0.05530 | Ubiquitin carboxyl-terminal hydrolase 14 |
DNM1L | 5.1 | 0.04185 | 0.06481 | Dynamin-1 |
DBNL | 5.1 | 0.18936 | 0.22434 | Drebrin |
TOMM70A | 5 | 0.12050 | 0.11536 | Mitochondrial import receptor subunit TOM70 |
UBA1 | 4.9 | 0.06626 | 0.08523 | Ubiquitin-like modifier-activating enzyme 1 |
SND1 | 4.6 | 0.02578 | 0.03000 | Staphylococcal nuclease domain-containing protein 1 |
NNT | 4.6 | 0.03093 | 0.02652 | NAD(P) transhydrogenase, mitochondrial |
XRCC6 | 4.3 | 0.04042 | 0.05530 | KU-70 |
DLAT | 4.2 | 0.02720 | 0.02652 | Acetyltransferase component of pyruvate dehydrogenase complex |
ACOT7 | 4.1 | 0.15434 | 0.16372 | Cytosolic acyl coenzyme A thioester hydrolase |
PPP2R4 | 4.1 | 0.02578 | 0.02652 | Serine/threonine-protein phosphatase 2A activator |
PLXNA1 | 4.0 | 0.08108 | 0.10703 | Plexin-A1 |
PGRMC1 | 3.9 | 0.02447 | 0.01072 | Membrane-associated progesterone receptor component 1 |
VPS35 | 3.8 | 0.04996 | 0.04909 | Vacuolar protein sorting-associated protein 35 |
ATP2A2 | 3.8 | 0.04735 | 0.03000 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 |
KIF2C | 3.6 | 0.02777 | 0.03000 | Kinesin |
MAPK3 | 3.6 | 0.02082 | 0.02652 | Mitogen-activated protein kinase 3 |
HSPA12B | 3.5 | 0.53236 | 0.52338 | Heat shock 70 kDa protein 12B |
RTN4 | 3.2 | 0.04345 | 0.07768 | Reticulon-4 |
ARHGDIA | 3.2 | 0.08045 | 0.09469 | Rho GDP-dissociation inhibitor 1 |
FASN | 3 | 0.08108 | 0.02652 | Fatty acid synthase |
XRCC5 | 2.9 | 0.05787 | 0.11224 | KU-80 |
UCHL1 | 2 | 0.08705 | 0.03192 | Ubiquitin carboxyl-terminal hydrolase isozyme L1 |