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Table 1 Proteins more abundant in AD relative to control patients. Proteins in the same amount of 8 control and 8 AD cortical samples were determined by LC/MS/MS, generating spectral count data that reflects the relative amount of protein when two identical proteins are compared. The data are presented as the ratio of the spectral counts in AD divided by the control samples. A Wilcoxon rank-sum t test (on raw values) and a Welch’s t-test (on log-transformed quantile-normalized values) were performed to assess statistical significance between the two groups

From: Diverse proteins aggregate in mild cognitive impairment and Alzheimer’s disease brain

Protein nameRatio AD/controlAdjusted P value rank t testAdjusted P value, log/quant t testDescription
CAMK2G34.10.352840.36965Calcium/calmodulin-dependent protein kinase type II subunit gamma
VARS7.50.026520.02652Valine-tRNA ligase
CORO1A6.40.002920.01072Coronin
UBC6.10.188820.16372Polyubiquitin-C
APOE60.248530.25648Apolipoprotein E
CADPS5.90.024060.02181Calcium-dependent secretion activator 1
UBB5.90.188820.16481Ubiquitin
UBA525.80.074780.05029Ubiquitin-60S ribosomal protein L40
FN15.50.276850.26619Fibronectin
CRMP15.40.159190.15661Dihydropyrimidinase-related protein 1
GPI5.30.045300.02897Glucose-6-phosphate isomerase
USP145.20.050720.05530Ubiquitin carboxyl-terminal hydrolase 14
DNM1L5.10.041850.06481Dynamin-1
DBNL5.10.189360.22434Drebrin
TOMM70A50.120500.11536Mitochondrial import receptor subunit TOM70
UBA14.90.066260.08523Ubiquitin-like modifier-activating enzyme 1
SND14.60.025780.03000Staphylococcal nuclease domain-containing protein 1
NNT4.60.030930.02652NAD(P) transhydrogenase, mitochondrial
XRCC64.30.040420.05530KU-70
DLAT4.20.027200.02652Acetyltransferase component of pyruvate dehydrogenase complex
ACOT74.10.154340.16372Cytosolic acyl coenzyme A thioester hydrolase
PPP2R44.10.025780.02652Serine/threonine-protein phosphatase 2A activator
PLXNA14.00.081080.10703Plexin-A1
PGRMC13.90.024470.01072Membrane-associated progesterone receptor component 1
VPS353.80.049960.04909Vacuolar protein sorting-associated protein 35
ATP2A23.80.047350.03000Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
KIF2C3.60.027770.03000Kinesin
MAPK33.60.020820.02652Mitogen-activated protein kinase 3
HSPA12B3.50.532360.52338Heat shock 70 kDa protein 12B
RTN43.20.043450.07768Reticulon-4
ARHGDIA3.20.080450.09469Rho GDP-dissociation inhibitor 1
FASN30.081080.02652Fatty acid synthase
XRCC52.90.057870.11224KU-80
UCHL120.087050.03192Ubiquitin carboxyl-terminal hydrolase isozyme L1
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