Fig. 4From: Young blood plasma reduces Alzheimer’s disease-like brain pathologies and ameliorates cognitive impairment in 3×Tg-AD miceYoung plasma improves spatial learning in 3×Tg-AD mice. a–d, Morris water maze test. The escape latency (a) to reach the hidden platform during acquisition phase for 4 days (two-way ANOVA, F = 9.77, dfd = 72, p = 0.0026), and the number of target area crossings (b), percentage of time in the target quadrant (c), and the average swim speed (d) of mice during the probe test. e–h Reversal Morris water maze test. The escape latency (e) to reach the hidden platform during acquisition phase for 3 days (two-way ANOVA, F = 17.17, dfd = 76, p < 0.0001), and the number of target area crossings (f), percentage of time in the target quadrant (g), and the average swim speed (h) during the probe test. Unpaired t test was used for b–d and f–h. N = 10 for young plasma treatment, n = 11 for vehicle (saline) controlBack to article page