CN | MCI | AD | p value | ||
---|---|---|---|---|---|
n | – | 144 AIBL, 94 KARVIAH | 21 | 25 | NA |
Age | Years (s.d.) | 75 (7.362) | 75 (6.226) | 71 (9.072) | 0.170 |
Female | n (%) | 105 (44%) | 9 (43%) | 13 (52%) | 0.743 |
APOE-ɛ4 +ve | n (%) | 75 (32%) | 10 (48%) | 18b (72%) | 1.46 × 10−4 |
PIB-PET# | SUVR (s.d.) | 1.425 (0.033) | 1.853a (0.089) | 2.374b,c (0.086) | 3.224 × 10−20 |
MRI hippocampus (right, cm3)# | Mean (s.d.) | 3.102 (0.030) | 2.970 (0.106) | 2.858b (0.107) | 0.008 |
MRI hippocampus (left, cm3)# | Mean (s.d.) | 3.200 (0.031) | 3.142 (0.108) | 3.075b (0.109) | 3.600 × 10−5 |
MRI gray matter (cm3)# | Mean (s.d.) | 671 (4.611) | 694 (16.207) | 633b,c (16.316) | 0.029 |
MRI white matter# (cm3) | Mean (s.d.) | 437 (4.514) | 438 (15.866) | 449 (15.973) | 0.660 |
MMSE | Mean (s.d.) | 28.592 (0.119) | 27.027a (0.388) | 20.686b,c (0.382) | 9.453 × 10−54 |
CDR scores# | Mean (s.d.) | 0.027 (0.013) | 0.493a (0.036) | 0.827b,c (0.035) | 9.139 × 10−56 |
CDR sum of boxes# | Mean (s.d.) | 0.039 (0.045) | 1.325a (0.134) | 4.163b,c (0.125) | 3.384 × 10−73 |