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Table 1 Baseline demographic and clinical characteristics of CN, MCI, and AD subjects

From: Plasma transferrin and hemopexin are associated with altered Aβ uptake and cognitive decline in Alzheimer’s disease pathology

 

CN

MCI

AD

p value

n

144 AIBL, 94 KARVIAH

21

25

NA

Age

Years (s.d.)

75 (7.362)

75 (6.226)

71 (9.072)

0.170

Female

n (%)

105 (44%)

9 (43%)

13 (52%)

0.743

APOE-ɛ4 +ve

n (%)

75 (32%)

10 (48%)

18b (72%)

1.46 × 10−4

PIB-PET#

SUVR (s.d.)

1.425 (0.033)

1.853a (0.089)

2.374b,c (0.086)

3.224 × 10−20

MRI hippocampus (right, cm3)#

Mean (s.d.)

3.102 (0.030)

2.970 (0.106)

2.858b (0.107)

0.008

MRI hippocampus (left, cm3)#

Mean (s.d.)

3.200 (0.031)

3.142 (0.108)

3.075b (0.109)

3.600 × 10−5

MRI gray matter (cm3)#

Mean (s.d.)

671 (4.611)

694 (16.207)

633b,c (16.316)

0.029

MRI white matter# (cm3)

Mean (s.d.)

437 (4.514)

438 (15.866)

449 (15.973)

0.660

MMSE

Mean (s.d.)

28.592 (0.119)

27.027a (0.388)

20.686b,c (0.382)

9.453 × 10−54

CDR scores#

Mean (s.d.)

0.027 (0.013)

0.493a (0.036)

0.827b,c (0.035)

9.139 × 10−56

CDR sum of boxes#

Mean (s.d.)

0.039 (0.045)

1.325a (0.134)

4.163b,c (0.125)

3.384 × 10−73

  1. ANCOVA models adjusted for age, sex, and APOEε4 genotype. The mean and standard deviation (s.d.) are presented in the table with false discovery rate correction set at 5%
  2. aCN vs MCI
  3. bCN vs AD
  4. cMCI vs AD
  5. #AIBL group only