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Table 5 Effect of exercise under exposure to the 40-Hz light flickering on apoptosis and cell death in the hippocampus

From: Physical exercise during exposure to 40-Hz light flicker improves cognitive functions in the 3xTg mouse model of Alzheimer’s disease

Group

Bax

Bcl-2

Cytochrome c

Caspase-3

TUNEL (mm2)

CON

1.00 ± 0.14

1.00 ± 0.03

1.00 ± 0.05

1.00 ± 0.08

26.68 ± 2.63

AD

2.14 ± 0.11*

0.31 ± 0.05*

1.74 ± 0.07*

1.79 ± 0.08*

109.06 ± 5.92*

AD+40

1.60 ± 0.05*#

0.62 ± 0.05*#

1.42 ± 0.04*#

1.49 ± 0.04*#

59.59 ± 3.48*#

AD+EX

1.62 ± 0.07*#

0.68 ± 0.04*#

1.39 ± 0.04*#

1.41 ± 0.03*#

57.71 ± 4.34*#

AD+40+EX

0.99 ± 0.09*#+

1.29 ± 0.09*#+

0.90 ± 0.06*#+

0.96 ± 0.02*#+

32.99 ± 3.35*#+

  1. *P < .05 compared to the CON group, #P < .05 compared to the AD group, +P < .05 compared to the AD+40 and AD+EX