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Table 1 Demographic characteristics of the included studies

From: Testing whether the progression of Alzheimer’s disease changes with the year of publication, additional design, and geographical area: a modeling analysis of literature aggregate data

 

Overall

Trial with non-add-on design

Trial with add-on design

Trials before 2008

Trials after 2008

Number of trials

140

113

27

64

76

Total sample size

19,210

14,556

4654

7008

12,202

Sample size per arm*

102 (11, 746)

100 (11, 746)

132 (21, 479)

107 (14, 327)

101 (11, 746)

Age, years*

73.5 (58.0, 81.7)

73.3 (58.0, 81.7)

74.1 (68.0, 79.4)

73.2 (58.0, 78.9)

73.6 (64.6, 81.7)

Gender, male (%)*

42.1 (0, 98.0)

41.2 (0,67)

43.3 (0, 98.0)

42.6 (27.1, 67.0)

41.9 (0, 98.0)

Race, white (%)*

93.7 (0, 100)

93.1 (0, 100)

94.1 (0, 100)

92.6 (0, 100)

94.1 (0, 100)

APOE ε4 carrier, %*

58.4 (0, 100)

58.1 (0, 100)

58.3 (46.6, 74.0)

60.0 (53.0, 67.6)

57.9 (0, 100)

ADAS-cog 11, points*

24.5 (13.1, 39.3)

24.8 (13.1, 39.3)

24.1 (17.6, 28.0)

26.4 (16.2, 39.3)

24.0 (13.1, 32.2)

NPI score, points*

9.3 (5.0, 21.8)

9.6 (5.0, 21.1)

9.0 (5.8, 21.8)

11.0 (8.7, 16.1)

9.1 (5.0, 21.8)

MMSE score, points*

19.4 (13.2, 25.4)

19.4 (13.2 25.4)

19.5 (15.6, 22.2)

19.1 (13.2, 22.5)

20.1 (15.6, 25.4)

Publication year, no. (%)

 Before 2008

64 (45.7)

64 (61.2)

0 (0)

 After 2008

76 (54.3)

49 (38.8)

27 (100)

  1. *Reported mean data were express as median (minimum–maximum)