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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Testing whether the progression of Alzheimer’s disease changes with the year of publication, additional design, and geographical area: a modeling analysis of literature aggregate data

Fig. 2

a Plot of the individual estimate of disease progression rate α derived from the base model versus the baseline ADAS-cog score. The two parameter-covariate relationships, power and U-type function, were demonstrated by using blue and red lines, respectively. b Plot of the individual estimate of disease progression rate α derived from the base model versus the baseline age. The blue fitted line demonstrated the correlation between them. In plot (a) and (b), each black circle stands for one independent study, and the circle size is proportional to the corresponding sample size. c A surface diagram to describe the relationship among age, ADAS-cog score, and the disease progression rate. Younger patients with higher baseline ADAS-cog score were predicted to manifest faster cognitive decline

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Alzheimer's Research & Therapy

ISSN: 1758-9193