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Table 2 Summary of pathways enriched in KEGG of proteins associated with aggregated amyloid according to APOE ε4 genotype

From: APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer’s disease

Cognitive stage

APOE ε4 carriers

APOE ε4 non-carriers

Pathway enriched

pFDR

Proteins

Pathway enriched

pFDR

Proteins

MMSE > 27

Complement and coagulation cascades

8.20E−12

C2, C3, C5, C6, CFB, CFH, F2, KNG1, PLG

Cell adhesion molecules

0.000165

CADM3’, NRXN2, NRXN1, CNTN1, CNTNAP2

MMSE 27–24

No enrichment detected

n.a.

n.a.

Complement and coagulation cascades

8.61E−13

C2, C3, C5, C6, CFB, F2, KNG1, PLG

MMSE < 24

Cell adhesion molecules

8.44E−09

CADM3’, CNTN1, CNTNAP2, NCAM1, NEGR1, NEO1, NRCAM, NRXN1, NRXN2, PVRL1’

No enrichment detected

n.a.

n.a.

  1. Please note that APOE and APP were excluded from enrichment analyses. Bold font indicates concordant difference compared to controls observed in EMIF-AD MBD; apostrophe (’) indicates not available in independent cohort
  2. n.a not applicable, MMSE Mini-Mental State Examination, FDR false discovery rate