From: APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer’s disease
Cognitive stage | APOE ε4 carriers | APOE ε4 non-carriers | ||||
---|---|---|---|---|---|---|
Pathway enriched | pFDR | Proteins | Pathway enriched | pFDR | Proteins | |
MMSE > 27 | Complement and coagulation cascades | 8.20E−12 | C2, C3, C5, C6, CFB, CFH, F2, KNG1, PLG | Cell adhesion molecules | 0.000165 | CADM3’, NRXN2, NRXN1, CNTN1, CNTNAP2 |
MMSE 27–24 | No enrichment detected | n.a. | n.a. | Complement and coagulation cascades | 8.61E−13 | C2, C3, C5, C6, CFB, F2, KNG1, PLG |
MMSE < 24 | Cell adhesion molecules | 8.44E−09 | CADM3’, CNTN1, CNTNAP2, NCAM1, NEGR1, NEO1, NRCAM, NRXN1, NRXN2, PVRL1’ | No enrichment detected | n.a. | n.a. |