Fig. 3
From: APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer’s disease
Effect size plots for 114 proteins measured in both ADNI and EMIF-AD MBD studies. a Effects for protein differences of individuals with abnormal amyloid carrying and ≥ 1 APOE ε4 allele against controls (i.e., APOE ε4 non-carriers with normal amyloid and MMSE > 27) according to the severity of their cognitive impairment (MMSE > 27, 27–24, or < 24), and at the far left for APOE ε4 carriers with normal amyloid and MMSE > 27. In blue, effect sizes and 95%CI for ADNI; in orange, for EMIF-AD MBD. b Effects for protein differences of individuals with abnormal amyloid carrying without an APOE ε4 allele against controls (i.e., APOE ε4 non-carriers with normal amyloid and MMSE > 27) according to the severity of their cognitive impairment (MMSE > 27, 27–24, or < 24). In blue, effect sizes and 95%CI for ADNI; in orange, for EMIF-AD MBD