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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not

Fig. 3

Cell-free assay shows GSM and iGSM affect PS1 and PS2 processivity with different efficiency. a 20 μg rC100sub was incubated with WT, PS1, or PS2 membrane in the presence of DMSO, 1 μM GSM1, 1 μM Compound 2, or 100 μM of fenofibrate. IP-MS of Aβ peptide with Ab5 antibody. b IP-MS of AICD with Anti-FLAG M2 antibody. c Percentage change of Aβ38 in cell-free assay with GSMs presented in a. The sum of peak intensities of Aβ38 and Aβ40 was set as 100%. Analysis of statistical significance was performed by one-way ANOVA with Tukey’s multiple comparisons test using Prism GraphPad version 8 software (n = 3, *p < 0.05, ** p < 0.01)

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Alzheimer's Research & Therapy

ISSN: 1758-9193