Skip to main content

Table 1 Baseline demographic and clinical characteristics of the ADNI and NGF cohorts

From: The cholinergic system in subtypes of Alzheimer’s disease: an in vivo longitudinal MRI study

 

ADNI cohort

NGF cohort

p value

HC

AD patients

AD subtypes

AD patients

ADNI (4 AD subtypes and HC)

ADNI (AD) and NGF (AD)

Typical AD

Limbic-predominant AD

Hippocampal-sparing AD

Minimal atrophy AD

Baseline, n

69

90

46

18

15

11

10

  

6 months, n

69

83

41

18

14

10

4#

  

12 months, n

64

68

31

17

13

7

6#

  

24 months, n

43

54

27

13

9

5

–

  

Sex, % female

51%

42%

28%

56%

47%

73%

50%

.035‡

.641

Age

75.3 (5.4)

74.2 (7.7)

75.6 (6.2)

74.5 (6.9)

75.8 (9.1)

65.2 (7.4)*,†

62.5 (5.7)

< .001

< .001

Years of education

15.9 (2.7)

15.2 (3.3)

15.3 (3.8)

15.1 (1.8)

15.3 (3.4)

14.6 (3.1)

12.1 (4.0)

.761

.007

CDR total, % (0.5/1)

0/0

56/44

50/50

67/33

60/40

55/45

50/50

.671§

.741

MMSE

29 (1.1)

23.4 (1.9)

23.0 (1.8)

23.8 (1.9)

23.7 (1.9)

24.2 (1.2)

21.4 (2.4)

.126§

.002

APOE, % ε4 carriers

9%

74%

76%†

83%†

53%†

82%†

80%

< .001

.199

  1. The table shows count for number of participants at baseline, 6-, 12-, and 24-month follow-ups; mean and standard deviation (SD) for age, years of education, and MMSE; and percentage for sex, CDR total, and APOE ε4 carriers at baseline
  2. Abbreviations: n sample size, CDR clinical dementia rating, MMSE Mini-Mental State Examination, APOE apolipoprotein E, ε4 allele epsilon 4, AD Alzheimer’s disease, HC healthy controls, ADNI Alzheimer’s Disease Neuroimaging Initiative, NGF nerve growth factor
  3. *Significantly different to typical AD, limbic-predominant, and hippocampal-sparing
  4. †Significantly different to healthy controls. Bold numbers indicate p values under 0.05
  5. ‡Post hoc analysis showed no differences between the five ADNI groups
  6. §CDR and MMSE p values are reported for the comparison between the AD subtypes (excluding HC)
  7. #NGF patients with 6- and 12-month follow-up corresponded to different participants. Two of the NGF patients with 6 months follow-up were classified as typical AD subtype, one limbic-predominant, and one hippocampal-sparing subtype. Regarding the other six NGF patients with 12 months follow-up, four were classified as hippocampal-sparing and two as typical AD subtype
Back to article page

Alzheimer's Research & Therapy

ISSN: 1758-9193