Fig. 5

NJK14047 treatment from 6 to 9 months of age upregulates the expression levels of microglial phagocytic receptors and the Aβ clearance function of microglia. a Relative mRNA expression levels of microglial phagocytic receptors in the cortex and hippocampus were measured using qRT-PCR. The expression levels were normalized to GAPDH levels and shown as the fold change with respect to the mean of the control group with SD (n = 5–6 per group, Kruskal-Wallis test). b Representative confocal microscope images for phagocytic microglia stained with thioflavin S and Iba-1 antibody (scale bar = 30 μm). Microglial cell counts within the 20-μm range of Aβ plaque were quantified. Data were shown as mean ± SEM (n = 5 per group, Student’s t test). ^#P < 0.05 vs. wild type; *P < 0.05 vs. 5XFAD