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Fig. 7 | Alzheimer's Research & Therapy

Fig. 7

From: Reduction of NgR in perforant path decreases amyloid-β peptide production and ameliorates synaptic and cognitive deficits in APP/PS1 mice

Fig. 7

The proposed effect of NgR reduction on APP traffic to lysosome through Rho/ROCK2 pathway. Full-length APP is synthesized in the endoplasmic reticulum (ER) and transported to the cell surface or endosomes/lysosomes. Once APP is transported to the cell surface, it undergoes amyloidogenic or non-amyloidogenic processing by β-secretase or α-secretase cleavage. While partial APP is internalized and delivered to endosome, a fraction of endocytosed APP molecules is recycled back to the cell surface, and other fractions are either processed in the endosome to release Aβ or delivered to lysosome for degradation. NgR reduction suppresses the downstream Rho/ROCK2 signaling pathway which enhances APP traffic to lysosomes, thus may reduce APP distribution to other cellular compartments and decrease Aβ production

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Alzheimer's Research & Therapy

ISSN: 1758-9193