Fig. 1

Knockdown of NgR in the perforant path attenuates cognitive impairment in APP/PS1 transgenic mice. TG-vector: AAV-vector APP/PS1 transgenic mice. TG-shNgR: AAV-shNgR APP/PS1 transgenic mice. A Mice were subjected to the Morris water maze test, B the passive avoidance test, and the C Y-maze spontaneous alteration test. A (a) The mean escape latency. A (b) Tracings of the typical swim patterns. A (c, d) The swimming speed during the acquisition training and the test phase. A (e) The number of crossing of the platform area. A (f) The percentage of the time spent by the mice in the target quadrant. B (a, b) The latency of APP/PS1 transgenic mice during the passive avoidance test. C The alternation score of the Y-maze spontaneous alteration test. Data are presented as mean ± SEM. n = 13 male mice/group. Data in A (a) and (c) were analyzed by repeated measures ANOVA with post hoc test, **P < 0.01. Data in A (d, f), B, and C were analyzed by Student’s t test, TG-shNgR mice vs TG-vector mice. *P < 0.05; **P < 0.01