Table 1 Animal studies discussed in the present review
From: Are ketogenic diets promising for Alzheimer’s disease? A translational review
Study 1st author (ref) | Models | Intervention | Number | FU | Outcomes | Positive results (intervention group) | Nutritional changes (vs ctrl group) |
|---|---|---|---|---|---|---|---|
Aso [17] | APP/PS1 mice | KD + triheptanoin vs KD | 28 | 12 | Cognition, AD features inflammation markers | Cognition and neuroinflammation | Unassessed |
Beckett [18] | APP/PS1 mice | KD ad libitum | 65 | 4 | Motor functions, AD features, oxidative stress | Motor coordination (rotarod) | Weight loss |
Brownlow [19] | APP/PS1 and Tg4510 mice | KD ad libitum | 60 | 16 | Cognition, motor unctions, AD features | Motor coordination (rotarod) | Stable weight |
Hernandez [20] | Young vs old WT rats | KD cal ctrl | 56 | 12 | Body composition, transporter expression | Less adipose tissues and reversed age-related transporters evolution | Unassessed |
Hernandez [21] | Young vs old WT rats | KD cal ctrl | 39 | 12 | Cognition, transporter expression | Cognition and reversed age-related transporters evolution | Weight loss in old rats |
Kashiwaya [22] | 3xTgAD mice | KS vs CD | 30 | 32 | Cognition, AD features | Cognition and AD features | Weight loss |
Newman [23] | Young vs old WT mice | Cyclic KD ad libitum | 58 | 72 | Cognition, motor functions, health span, gene expression | Cognition and reduced mid-life mortality | Stable weight |
Pan [24] | Old beagle dogs | KS vs CD | 24 | 32 | Cognition | Cognition | Stable weight |
Pawlosky [25] | 3xTgAD mice | KS vs CD | 24 | 32 | Metabolism, protein expression | Reduced protein oxidation and BACE 1 expression | Weight loss |
Van der Auwera [26] | APP/V717I mice | KD ad libitum, crossover | 16 | 6 | Cognition, AD features | Reduced brain total Aβ | Weight loss |
Wang [27] | Old WT rats | KS (MCT 8 or 10) vs CD | 36 | 8 | Cognition, synapse pathway | Cognition and synaptic stability | Weight loss |