Skip to main content

Table 1 Top 5 S-PrediXcan associations by APOE region

From: An analysis of genetically regulated gene expression across multiple tissues implicates novel gene candidates in Alzheimer’s disease

Gene

Chr

Most significant tissue

SNPs

Tissues

Z score

P value

Inside APOE

 APOE

19

Skin, sun-exposed leg

10

3

− 19.50

1.03 × 10−84

 NECTIN2

19

Oesophagus muscularis

3

8

− 19.28

8.32 × 10− 83

 APOC1

19

Adrenal gland

3

3

− 19.13

1.48 × 10−81

 BLOC1S3

19

Oesophagus muscularis

9

1

− 15.63

4.29 × 10−55

 RELB

19

Lung

24

1

11.55

7.14 × 10−31

Outside APOE

 VASP

19

Testis

53

1

− 11.30

1.24 × 10−29

 SIX5

19

Skin, sun-exposed leg

40

2

10.28

8.60 × 10−25

 CD3EAP

19

Substantia nigra

6

1

10.06

8.65 × 10−24

 ZNF155

19

Minor salivary gland

62

2

− 8.45

3.02 × 10−17

 CLU

2

Skin, sun-exposed leg

5

2

8.22

2.04 × 10−16

  1. Chr chromosome; N SNPs are the number of eQTLs included in the MetaXcan prediction model; N tissues are the N tissues with P value < 7.63 × 10−7; Z score represents the strength of association between gene expression and disease risk. Positive values indicate that an increased level of gene expression is associated with increased disease risk, while negative values indicate that a reduced level of gene expression increases disease risk