The relationship between physical activity, apolipoprotein E ε4 carriage, and brain health

de Frutos-Lucas, Jaisalmer; Cuesta, Pablo; López-Sanz, David; Peral-Suárez, África; Cuadrado-Soto, Esther; Ramírez-Toraño, Federico; Brown, Belinda M.; Serrano, Juan M.; Laws, Simon M.; Rodríguez-Rojo, Inmaculada C.; Verdejo-Román, Juan; Bruña, Ricardo; Delgado-Losada, Maria L.; Barabash, Ana; López-Sobaler, Ana M.; López-Higes, Ramón; Marcos, Alberto; Maestú, Fernando

doi:10.1186/s13195-020-00608-3

Alzheimer's Research & Therapy

Table 4 Correlation analyses

From: The relationship between physical activity, apolipoprotein E ε4 carriage, and brain health

	Whole sample						Carriers						Non-carriers
	mθTPA		mδTPA		mδMVPA		mθTPA		mδTPA		mδMVPA		mθTPA		mδTPA		mδMVPA
	Rho	p	Rho	p	Rho	p	Rho	p	Rho	p	Rho	p	Rho	p	Rho	p	Rho	p
Forward digits	− 0.20	0.03	− 0.18	0.061	− 0.20	0.04	− 0.30	0.09	− 0.08	0.66	− 0.04	0.84	− 0.17	0.14	− 0.23	0.05	− 0.28	0.01
Reverse digits	− 0.23	0.02	− 0.21	0.03	− 0.22	0.03	− 0.29	0.11	− 0.23	0.20	− 0.22	0.23	− 0.23	0.05	− 0.22	0.06	− 0.22	0.06
Logical mem. units	− 0.00	0.96	− 0.00	0.99	− 0.03	0.78	− 0.11	0.54	− 0.16	0.40	− 0.12	0.51	0.05	0.65	0.09	0.47	0.06	0.63
Logical mem. gist	− 0.18	0.07	− 0.27	0.01	− 0.23	0.02	− 0.09	0.62	− 0.13	0.51	− 0.09	0.66	− 0.20	0.10	− 0.34	0.01	− 0.30	0.01
Anxiety	0.29	< 0.01	0.22	0.03	0.2	0.05	0.46	0.01	0.28	0.15	0.29	0.13	0.20	0.09	0.19	0.13	0.16	0.18
Depression	0.08	0.423	0.08	0.43	0.079	0.44	− 0.04	0.84	− 0.06	0.72	− 0.11	0.54	0.14	0.25	0.17	0.17	0.20	0.10
Total GM	− 0.27	0.01	− 0.29	< 0.01	− 0.29	< 0.01	− 0.39	0.03	− 0.44	0.01	− 0.43	0.02	− 0.23	0.05	− 0.23	0.05	− 0.23	0.05
Amygdala	− 0.28	< 0.01	− 0.27	< 0.01	− 0.27	< 0.01	− 0.33	0.07	− 0.41	0.02	− 0.39	0.03	− 0.25	0.03	− 0.21	0.08	− 0.21	0.07
Hippocampus	− 0.26	0.01	− 0.27	< 0.01	− 0.28	< 0.01	− 0.50	< 0.01	− 0.47	0.01	− 0.42	0.02	− 0.16	0.18	− 0.17	0.15	− 0.20	0.08
Precuneus	− 0.14	0.15	− 0.20	0.04	− 0.21	0.03	− 0.15	0.41	− 0.42	0.02	− 0.42	0.02	− 0.11	0.35	− 0.10	0.42	− 0.10	0.41
Global FA	− 0.03	0.72	− 0.08	0.43	− 0.04	0.69	− 0.18	0.33	− 0.16	0.38	− 0.11	0.56	− 0.00	0.97	− 0.04	0.73	− 0.00	0.98
Uncinate	− 0.24	0.02	− 0.18	0.07	− 0.14	0.16	− 0.61	< 0.01	− 0.44	0.01	− 0.39	0.03	− 0.07	0.58	− 0.07	0.59	− 0.01	0.91
Parahippocampus	− 0.00	0.96	− 0.07	0.49	− 0.03	0.76	− 0.17	0.37	− 0.30	0.10	− 0.22	0.23	0.05	0.68	0.03	0.77	0.07	0.55

Results for Spearman’s correlation analyses between mean FC-st of each main cluster (mθTPA, mδTPA, and mδMVPA) and a series of AD markers (rho and p values) are shown. The list of variables includes the following: working memory (Forward and Reverse Digit Span—forward and reverse digits); episodic memory (Logical Memory II—delayed recall; for units and gist—logical mem. units and gist); anxiety (Goldberg’s test); depression (Geriatric Depression Scale); total gray matter volume (GM, in cubic millimeter); hippocampus, amygdala, and precuneus volumes (left plus right, in cubic millimeter); global fractional anisotropy (FA); and uncinate and parahippocampal fasciculus fractional anisotropy (left and right weighted arithmetic mean). Outcomes that were significant for α < 0.05 and FDR q = 0.1 are bolded

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