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Table 2 Unadjusted and adjusted model showing the association between methotrexate and sulfasalazine treatment and dementia diagnosis in people with rheumatoid arthritis using conditional logistic regression

From: Methotrexate and relative risk of dementia amongst patients with rheumatoid arthritis: a multi-national multi-database case-control study

Drug

Model 0

Model 1

Model 2

Unadjusted OR (95% CI)

p value

Adjusted OR (95% CI)

p value

Adjusted OR (95% CI)

p value

Methotrexate

0.76 (0.56–1.03)

0.076

0.72 (0.52–0.98)

0.036

0.71 (0.52–0.98)

0.034

Sulfasalazine

0.88 (0.57–1.36)

0.56

0.89 (0.57–1.38)

0.60

0.88 (0.57–1.37)

0.57

  1. Model 0, no adjustment; model 1, adjustment for age, BMI, stroke and AMI; model 2, same as model 1 but not including diagnosis of stroke. OR odds ratio for dementia risk