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Table 1 Characteristics of cases and controls (with and without dementia) with rheumatoid arthritis used in this study

From: Methotrexate and relative risk of dementia amongst patients with rheumatoid arthritis: a multi-national multi-database case-control study

 

Case (with dementia diagnosis)

Control (no dementia diagnosis)

p value

n

486

641

–

Age at index date (years)

79.8 (± 6.89)

79.5 (± 7.02)

0.522

Gender

86.4% F

87.4% F

0.707

Time since rheumatoid arthritis diagnosis before the index date (years)

6.87 (± 6.29)

7.06 (± 5.92)

0.232

Prescribed with sulfasalazine

40 (8.23%)

57 (8.89%)

0.776

Years of sulfasalazine use before the index date

2.72 (± 3.57)

2.57 (± 3.96)

0.457

Prescribed with methotrexate

123 (25.3%)

178 (27.77%)

0.392

Years of methotrexate use before the index date

2.69 (± 3.06)

3.80 (± 2.44)

0.002

Prescribed with methotrexate or sulfasalazine

19 (3.91%)

25 (3.90%)

1.000

Diagnosed with AMI

26 (5.35%)

34 (5.30%)

1.000

Diagnosed with stroke

37 (7.60%)

64 (10.00%)

0.202

Highest BMI before the index date

28.1 (± 4.99)

28.8 (± 4.90)

0.061

BMI missingness

178 (36.62%)

211 (32.92%)

0.217

Total time in database (years)

7.64 (± 7.82)

7.77 (± 7.66)

0.301

Time in database before the index date (years)

5.16 (± 7.47)

4.62 (± 7.01)

0.027

  1. Case, diagnosis of dementia; control, no diagnosis of dementia. For the calculation of p values to compare the demographics between cases and controls, an unpaired t test was applied for normally distributed numerical demographics, a Wilcoxon unpaired t test was applied for non-normally distributed numerical demographics and a chi-square test for categorical demographics was applied