Alzheimer's Research & Therapy

Table 5 Linear regression analysis output of the association of retinal thickness at baseline with FBB global SUVR at v0 and v2

From: Association between retinal thickness and β-amyloid brain accumulation in individuals with subjective cognitive decline: Fundació ACE Healthy Brain Initiative

Retinal regions	FBB global SUVR at v0					FBB global SUVR at v2
Retinal regions	B	95% CI	t	β	p	B	95% CI	t	β	p
Peripapillary RNFL
Total	− 0.001	− 0.001–0.000	− 1.87	− 0.16	0.06	− 0.001	− 0.001–0.000	− 1.66	− 0.14	0.10
Temporal	0.000	− 0.001–0.001	− 1.28	− 0.11	0.20	0.000	− 0.001–0.000	− 1.03	− 0.09	0.31
Superior	0.000	0.000–0.000	− 0.27	− 0.02	0.79	0.000	0.000–0.000	− 0.12	− 0.12	0.91
Nasal	0.000	− 0.001–0.000	− 1.38	− 0.11	0.17	0.000	− 0.001–0.000	− 1.42	− 0.12	0.16
Inferior	0.000	0.000–0.000	− 0.31	− 0.03	0.76	0.000	− 0.001–0.000	− 0.40	− 0.03	0.69
ETDRS macula
Centre	0.000	0.000–0.001	2.37	0.19	0.02*	0.000	0.000–0.001	2.17	0.18	0.03*
Inner temporal	0.000	0.000–0.001	1.86	0.15	0.07	0.001	0.000–0.001	1.95	0.16	0.05
Inner superior	0.001	0.000–0.001	1.76	0.14	0.08	0.001	0.000–0.001	2.18	0.18	0.03*
Inner nasal	0.001	0.000–0.001	2.95	0.23	0.004*	0.001	0.000–0.002	3.27	0.26	0.001*
Inner inferior	0.001	0.000–0.001	2.23	0.18	0.03*	0.001	0.000–0.001	2.55	0.20	0.01*
Outer temporal	0.000	0.000–0.001	0.62	0.05	0.54	0.000	− 0.001–0.001	0.37	0.03	0.71
Outer superior	0.000	0.000–0.001	0.54	0.05	0.59	0.000	0.000–0.001	0.82	0.07	0.41
Outer nasal	0.000	0.000–0.001	1.25	0.10	0.21	0.001	0.000–0.001	1.65	0.13	0.10
Outer inferior	0.001	0.000–0.001	2.22	0.18	0.03*	0.001	0.000–0.001	2.25	0.19	0.03*
Macular multilayer
GCL+	0.001	− 0.001–0.003	1.05	0.09	0.30	0.001	− 0.001–0.003	0.86	0.08	0.39
RNFL	0.001	− 0.001–0.002	0.91	0.07	0.37	0.001	− 0.001–0.003	1.03	0.08	0.30

A linear regression model for each of the sixteen retinal thickness measures was executed using log-transformed FBB global SUVR as the outcome, for v0 and v2 separately. In all analysis age, gender, education, APOE ε4 status and OCT retinal image quality were included as covariates
*Statistical significance was set-up at p < 0.05
Abbreviations: APOE apolipoprotein E, CI confidence interval, ETDRS Early Treatment Diabetic Retinopathy Study, FBB florbetaben, GCL ganglion cell layer complex, OCT optical coherence tomography, OR odds ratio, RNFL retinal nerve fiber layer, SUVR standardized uptake value ratio, v0 baseline visit, v2 follow-up visit at 2 years

Back to article page

ISSN: 1758-9193

Contact us

General enquiries: journalsubmissions@springernature.com