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Table 2 Retinal thickness measurements by PET and clinical status

From: Association between retinal thickness and β-amyloid brain accumulation in individuals with subjective cognitive decline: Fundació ACE Healthy Brain Initiative

 

PET status (+/−) at v0

PET status (+/−) at v2

Clinical status at v2

Aβ−

Aβ+

Aβ−

Aβ+

SCD

MCI

n

114

15

107

22

114

15

FBB global SUVR

1.17 ± 0.05

1.57 ± 0.20

1.19 ± 0.06

1.61 ± 0.28

1.24 ± 0.16

1.41 ± 0.39

Peripapillary RNFL

 Total

100.74 ± 11.84

96.90 ± 19.38

101.27 ± 11.33

95.55 ± 18.40

100.123 ± 13.24

101.56 ± 10.24

 Temporal

74.02 ± 10.67

74.23 ± 15.23

74.33 ± 10.60

72.64 ± 14.05

73.84 ± 11.20

75.58 ± 11.62

 Superior

118.05 ± 19.75

118.27 ± 18.64

118.85 ± 18.46

114.14 ± 24.59

118.05 ± 19.91

118.26 ± 17.31

 Nasal

77.57 ± 16.28

74.24 ± 17.82

77.96 ± 15.75

73.45 ± 19.37

77.16 ± 16.77

77.41 ± 14.02

 Inferior

133.28 ± 17.62

128.62 ± 21.0

133.89 ± 17.82

127.14 ± 18.31

132.44 ± 18.50

134.97 ± 14.04

 Image quality

47.41 ± 7.42

46.87 ± 7.42

47.52 ± 7.48

46.50 ± 7.02

47.99 ± 7.12

42.44 ± 7.78

ETDRS macula

 Centre

249.67 ± 21.63

259.91 ± 23.14

249.07 ± 21.56

259.59 ± 22.32

250.03 ± 22.09

257.18 ± 20.63

 Inner temporal

300.01 ± 15.72

305.52 ± 15.55

299.56 ± 15.15

305.91 ± 17.76

300.10 ± 15.63

304.80 ± 16.48

 Inner superior

312.32 ± 14.54

316.96 ± 18.05

311.74 ± 14.11

318.30 ± 18.07

312.43 ± 14.83

316.14 ± 16.24

 Inner nasal

313.41 ± 14.26

321.38 ± 17.62

312.81 ± 13.64

321.71 ± 18.29

313.80 ± 14.89

318.35 ± 14.25

 Inner inferior

309.64 ± 14.37

316.04 ± 18.48

309.14 ± 13.87

316.46 ± 18.60

309.64 ± 14.49

316.05 ± 17.70

 Outer temporal

254.28 ± 14.26

250.72 ± 15.70

254.22 ± 14.10

252.15 ± 16.11

253.75 ± 14.00

254.75 ± 17.81

 Outer superior

269.66 ± 12.92

266.47 ± 16.49

269.48 ± 12.90

268.36 ± 15.65

269.28 ± 12.84

269.34 ± 17.27

 Outer nasal

285.87 ± 14.42

288.58 ± 18.38

285.80 ± 14.03

288.05 ± 18.71

285.65 ± 14.16

290.20 ± 19.58

 Outer inferior

258.75 ± 13.50

260.79 ± 20.32

258.85 ± 13.69

259.62 ± 17.67

258.43 ± 13.45

263.23 ± 20.12

 Image quality

47.60 ± 6.94

48.68 ± 6.40

47.76 ± 7.01

47.55 ± 6.26

48.53 ± 6.36

41.63 ± 7.70

Macular multilayer

 GCL+

64.32 ± 4.85

64.47 ± 4.54

64.36 ± 4.79

64.22 ± 4.94

64.42 ± 4.60

63.68 ± 6.25

 RNFL

38.02 ± 4.39

39.62 ± 4.96

38.06 ± 4.42

39.93 ± 4.74

38.17 ± 4.37

38.41 ± 5.31

 Image quality

47.06 ± 6.94

50.04 ± 5.95

47.19 ± 7.02

48.48 ± 6.17

47.62 ± 6.82

45.80 ± 7.33

  1. Data were expressed as mean ± standard deviation. OCT retinal measurements were expressed as thickness (μm) except for image quality
  2. Abbreviations: amyloid-β, FBB florbetaben, ETDRS Early Treatment Diabetic Retinopathy Study, GCL ganglion cell layer, MCI mild cognitive impairment, PET positron emission tomography, RNFL retinal nerve fiber layer, SCD subjective cognitive decline, SUVR standardized uptake value ratio, v0 baseline visit, v2 follow-up visit at 2 years