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Fig. 11 | Alzheimer's Research & Therapy

Fig. 11

From: Nrf2 activation through the PI3K/GSK-3 axis protects neuronal cells from Aβ-mediated oxidative and metabolic damage

Fig. 11

The main activation pathways of Nrf2. The diagram illustrates the main homeostatic pathways regulating the transcription factor Nrf2 proteosomal degradation and activation through its nuclear translocation. The figure indicates the sites of action of PI3K inhibitors LY294002 and Wortmannin, the GSK-3 inhibitor SB216763, as well as SFN, an electrophilic activator that disrupts the Nrf2-Keap1complex formation

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