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Table 2 Demographic, genetic, and clinical data in the MRI subsample

From: Association between insomnia and cognitive performance, gray matter volume, and white matter microstructure in cognitively unimpaired adults

 

Gray matter volume (VBM) analyses (n = 366)

White matter DWI (TBSS) analyses (n = 334)

 

Controls

Insomnia

p

Controls

Insomnia

p

Sample size, no. (%)

229

137

215

119

Age, years (SD)

56.7 (7.4)

56.7 (7.0)

.917

56.8 (7.6)

56.8 (6.9)

.962

Female, no. (%)

117 (51.1)

87 (63.5)

.021

111 (51.6)

76 (63.6)

.036

Education, years (SD)

13.9 (3.6)

13.7 (3.6)

.567

13.9 (3.6)

13.7 (3.6)

.648

APOE-ε4 allele status, no. (%)

 Non-carriers

118 (51.5)

69 (50.4)

.391

108 (50.2)

62 (51.7)

.108

 Heterozygotes

78 (34.1)

54 (39.4)

74 (34.4)

48 (40.7)

 Homozygotes

33 (14.4)

14 (10.2)

33 (15.4)

10 (7.6)

BMI, mean (SD), kg/m2

26.9 (4.3)

26.5 (3.8)

.353

26.8 (4.3)

26.5 (3.8)

.639

GADS (SD)

0.4 (0.98)

0.96 (1.7)

< .001

0.41 (1.0)

1.0 (1.7)

< .001

Hypertension, no. (%)

51 (22.3)

27 (19.7)

.562

44 (20.5)

23 (19.5)

.832

Dyslipidemia, no. (%)

64 (28.0)

42 (30.1)

.580

58 (27.0)

38 (32.2)

.314

Diabetes mellitus, no. (%)

7 (3.1)

3 (2.2)

.622

6 (2.8)

3 (2.5)

0.894

Physically active, no. (%)

141 (61.6)

95 (69.3)

.133

130 (60.5)

82 (69.5)

.101

Sleep duration, hours (SD)

7.2 (0.70)

6.7 (0.93)

< .001

7.2 (0.7)

6.7 (0.9)

< .001

Total intracranial volume (SD)

1520.4 (139.5)

1471.3 (156.7)

.002

1517.8 (136.5)

1474.0 (158.2)

0.009

  1. BMI body mass index, GADS Sum of Goldberg Anxiety and Depression Scale scores