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Table 1 Demographic and clinical characteristics of TREM2 rare variant carriers and non-carriers

From: Plasma levels of soluble TREM2 and neurofilament light chain in TREM2 rare variant carriers

 TREM2 non-carriers (n = 49)TREM2 rare variant carriers (n = 48)TREM2 rare variant carriers
p.R47H (n = 26)p.T96K (n = 8)p.D87N (n = 5)Others (n = 9)
Age, years (SD)76.1 (6.7)75.2 (7.3)73.9 (8.4)76.6 (4.8)72.4 (6.8)76.9 (4.1)
Female, n (%)27/49 (55.1)26/48 (54.2)12 (46.2)5 (55.5)3 (60)6 (75)
APOE ɛ4 carriers, n (%)24 (68.6)a21 (59.7)b11316
MMSE, n (SD)23.3 (5.0)23.1 (6.4)21 (7.5)25 (5.0)28.8 (4.5)24.7 (2.3)
Diagnosis, n (%)AD, 31/49 (63.3); MCI, 8/49 (16.3); Ctrl, 10/49 (20.4)AD, 28/48 (58.4); MCI, 10/48 (20.8); Ctrl, 10/48 (20.8)18/26 (69); 4/26 (15.5); 4/26 (15.5)2/9 (25.0); 3/9 (37.5); 3/9 (37.5)1/5 (16.7); 2/5 (33.3); 2/5 (50.0)7/9 (87.5); 1/9 (12.5); 0/9
sTREM2, ng/L (SD)8750 (5265)7346 (5526)7294 (6791)8761.8 (4840)6431 (4107)7009 (1889)
NFL, ng/L (SD)26.1 (17.1)24.6 (19.1)25.7 (23.8)25.2 (17.8)23.1 (7.7)21.3 (7.6)
  1. a = 14 individuals with missing APOE status
  2. b = 13 individuals with missing APOE status
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