Retinal thinning of inner sub-layers is associated with cortical atrophy in a mouse model of Alzheimer’s disease: a longitudinal multimodal in vivo study

Table 2 Summary of the main retinal (structural and functional) and brain (visual cortex) changes in 3×Tg-AD mice

Retinal structure (layer thickness)
Total retina	GCL+IPL		INL+OPL		ONL	IS+OS
↓	↓		↓		↑	↓
Retinal function
ERG
Scotopic				Photopic	Flicker
a_mix	b_rod	b_mix	OP1	b_cone	Base wave	First harmonic	Second harmonic
↑ Amplitude	↑ Amplitude	↑ Amplitude	↑ Amplitude	↑ Amplitude	↑ Amplitude	↑ Amplitude	↑ Amplitude
↓ Time to peak			↓ Time to peak		↓ Phase	↓ Phase	↑ Phase
PERG
No changes
Brain (visual cortex)
↓ Gray matter volume

ISSN: 1758-9193