| | MMSE score at baseline | Change in MMSE over time |
|---|
Predictors | β (SE) |
p
| β (SE) |
p
|
|---|
Aβ42 | 1.02 (0.45) | 0.027* | 0.01 (0.19) | 0.929 |
Aβ40 | 1.11 (0.43) | 0.012* | − 0.13 (0.22) | 0.551 |
Aβ38 | 1.03 (0.43) | 0.020* | − 0.11 (0.22) | 0.618 |
Aβ42/Aβ40 ratio | 0.29 (0.49) | 0.556 | 0.19 (0.20) | 0.340 |
Aβ42/Aβ38 ratio | 0.25 (0.48) | 0.594 | 0.18 (0.20) | 0.383 |
Aβ38/Aβ40 ratio | 0.43 (0.44) | 0.331 | 0.00 (0.23) | 0.976 |
- Data are presented as standardized estimates (β) with their standard error (SE) and p value. Linear mixed models were used with terms for time (years), CSF Aβ peptide measures, and an interaction term of CSF Aβ peptide measure × time as independent variables and MMSE score as the dependent variable. For all models, a random intercept and slope were assumed. Aβ peptide levels were transformed to z-scores. A beta coefficient of one (β = 1) therefore implies that a 1 standard deviation increase in CSF Aβ peptide was associated with a 1-point increase in MMSE score. The models (one model per CSF Aβ peptide) were adjusted for age, sex, and education
- Abbreviations: Aβ42 amyloid β1-42 determined with MSD ELISA assay, Aβ40 amyloid β1-40 determined with MSD ELISA assay, Aβ38 amyloid β1-38 determined with MSD ELISA assay
- *p < 0.05
