hTau Anle138b | hTau Vehicle | hTau pooled Baseline | Non-carrier controls (pooled) | |
---|---|---|---|---|
Immunohistochemistry Frontal cortex (%-area) | 6.1 ± 1.9** | 12.9 ± 1.8 | 0 | |
Immunohistochemistry Frontal cortex (CP13+ neurons, N/mm2) | 1366 ± 116** | 2039 ± 153 | 0 | |
Immunohistochemistry Hippocampus (%-area) | 1.9 ± 1.4** | 4.8 ± 0.4 | 0 | |
Immunohistochemistry Hippocampus (CP13+ neurons, N/mm2) | 534 ± 18** | 619 ± 13 | 0 | |
FDG-PET baseline Frontal cortex (SUVR) | 0.97 ± 0.02 | 1.02 ± 0.09 | 1.00 ± 0.07# | 1.10 ± 0.10 |
FDG-PET follow-up Frontal cortex (SUVR) | 1.03 ± 0.05* | 0.95 ± 0.03# | 1.09 ± 0.06 | |
FDG-PET change Frontal cortex (ΔSUVR) | + 0.06 ± 0.06* | − 0.07 ± 0.09 | + 0.01 ± 0.05 | |
FDG-PET baseline Hippocampus (SUVR) | 0.93 ± 0.03 | 0.98 ± 0.10 | 0.96 ± 0.08# | 1.06 ± 0.10 |
FDG-PET follow-up Hippocampus (SUVR) | 1.00 ± 0.07 | 0.93 ± 0.05## | 1.05 ± 0.07 | |
FDG-PET change Hippocampus (ΔSUVR) | + 0.06 ± 0.05 | − 0.05 ± 0.10 | + 0.00 ± 0.05 |