MRI measures | Total, n | Intervention, n = 59 | Control, n = 53 | p |
---|---|---|---|---|
Total intracranial volume, ml | 112 | 1581.4 (1112.4–2039.1) | 1524.4 (975.5–1962.1) | 0.13 |
Baseline | ||||
Total hippocampal volume, ml | 112 | 7.2 (4.6–9.1) | 7.0 (4.5–8.3) | 0.33 |
AD signature cortical thickness, mm | 112 | 2.8 (2.5–3.0) | 2.8 (2.5–3.1) | 0.87 |
Total GM volume, ml | 112 | 576.7 (443.4–677.3) | 563.4 (406.3–709.6) | 0.18 |
WML volume, ml | 100 | 11.9 (0.5–60.7) | 11.7 (0.7–74.4) | 0.95 |
2-year follow-up | ||||
Total hippocampal volume, ml | 112 | 7.0 (4.3–9.1) | 6.8 (4.1–8.3) | 0.27 |
AD signature cortical thickness, mm | 112 | 2.7 (2.5–3.1) | 2.7 (2.3–3.1) | 0.47 |
Total GM volume, ml | 112 | 568.6 (434.4–670.4) | 556.0 (414.8–698.5) | 0.19 |
WML volume, ml | 100 | 13.6 (0.4–59.9) | 13.0 (0.5–84.9) | 0.86 |
*Annual rate of change, % (SD) | ||||
Total hippocampal volume | 112 | − 1.30 (1.3) | − 1.50 (2.0) | 0.56 |
AD signature cortical thickness | 112 | − 0.68 (0.98) | − 0.39 (1.2) | 0.24 |
Total GM volume | 112 | − 0.70 (0.89) | − 0.60 (1.4) | 0.64 |
WML volume | 96 | 7.0 (28.4) | 11.6 (50.3) | 0.58 |