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Table 1 Descriptive characteristics and test scores separately for each diagnostic group

From: Assessing cognition and daily function in early dementia using the cognitive-functional composite: findings from the Catch-Cog study cohort

 

SCD (n = 14)

MCI (n = 80)

AD (n = 78)

DLB (n = 12)

p value

Post hoc between group comparisons*

Descriptives

 Age

68.1 (6.6)

73.6 (8.0)

71.3 (9.1)

68.3 (6.1)

.033

Non-significant

 Female (%)

8 (57.1%)

29 (36.3%)

39 (50%)

2 (16.7%)

.060

N.A.

 Education

15.2 (4.8)

13.7 (3.6)

13.2 (4.0)

13.6 (3.3)

.36

N.A.

 MMSE

29.3 (1.2)

26.7 (2.3)

24.0 (3.3)

24.4 (2.9)

< .001

SCD > MCI > AD; SCD >DLB

CFC components

 Cognitive composite

.88 (.50)

.19 (.50)

− .31 (.61)

− .35 (.71)

< .001

SCD > MCI > AD, SCD > DLB, MCI > DLB

 A-IADL-Q

.91 (.79)

.39 (.73)

− .48 (.84)

− .65 (.90)

< .001

SCD > AD; MCI < AD; SCD > DLB; MCI > DLB

 CFC score

.89 (.57)

.29 (.51)

− .39 (.61)

− .51 (.75)

< .001

SCD > MCI > AD; SCD > DLB; MCI > DLB

Reference measures

 CFI-SP

N.A.

6.9 (3.2)

4.9 (2.8)

N.A.

< .001

N.A.

 QoL-AD

N.A.

33.8 (5.3)

31.6 (5.2)

N.A.

.026

N.A.

 ZBI-12

N.A.

10.7 (7.7)

14.4 (7.9)

N.A.

.004

N.A.

 AES

N.A.

39.9 (10.5)

43.3 (10.0)

N.A.

.053

N.A.

Traditional tests

 ADAS-Cog

N.A.

22.2 (6.8)

28.5 (7.6)

N.A.

< .001

N.A.

 ADCS-ADL

N.A.

67.5 (7.8)

63.7 (8.8)

N.A.

.010

N.A.

 CDR-SB

N.A.

2.7 (1.9)

5.1 (2.2)

N.A.

< .001

N.A.

  1. Abbreviations: ADAS-Cog Alzheimer’s Disease Assessment Scale–Cognitive subscale, ADCS-ADL Alzheimer’s Disease Cooperation Study–Activity of Daily Living, AES Apathy Evaluation Scale, A-IADL-Q Amsterdam IADL Questionnaire, CDR-SB Clinical Dementia Rating Sum of Boxes, CFC cognitive-functional composite, CFI-SP Cognitive Function Instrument study partner version, MMSE Mini-Mental State Examination, QoL Quality of life, ZBI Zarit Burden Inventory
  2. *Based on Hochberg’s post hoc tests