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Table 5 Parameters in APP metabolism and synaptic proteins between genders of mice in different groups

From: Exposure to fluoride aggravates the impairment in learning and memory and neuropathological lesions in mice carrying the APP/PS1 double-transgenic mutation

 

APP/PS1

APP/PS1+LF

APP/PS1+HF

Male

Female

Male

Female

Male

Female

BACE1

0.51 ± 0.20

0.49 ± 0.40

0.70 ± 0.30

0.62 ± 0.25

0.77 ± 0.20

0.80 ± 0.75

ADAM10

0.53 ± 0.20

0.47 ± 0.10

0.24 ± 0.10

0.36 ± 0.15

0.30 ± 0.20

0.23 ± 0.25

BACE2

0.43 ± 1.10

0.57 ± 0.75

0.44 ± 1.20

0.54 ± 0.90

0.37 ± 0.35

0.46 ± 0.50

SNAP-25

0.43 ± 0.10

0.57 ± 0.10

0.50 ± 0.95

0.41 ± 0.15

0.28 ± 0.30

0.37 ± 0.25

SYP

0.54 ± 0.15

0.46 ± 0.15

0.36 ± 0.10

0.46 ± 0.10

0.33 ± 0.05

0.29 ± 0.10

  1. Notice: APP/PS1, amyloid precursor protein/presenilin 1; LF, lower fluoride; HF, high fluoride. The values shown are means ± SD (n = 5) as determined by analysis of variance (ANOVA), followed by the least significant differences post hoc test
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Alzheimer's Research & Therapy

ISSN: 1758-9193