Segmentation of medial temporal subregions reveals early right-sided involvement in semantic variant PPA

Bocchetta, Martina; Iglesias, Juan Eugenio; Russell, Lucy L.; Greaves, Caroline V.; Marshall, Charles R.; Scelsi, Marzia A.; Cash, David M.; Ourselin, Sebastien; Warren, Jason D.; Rohrer, Jonathan D.

doi:10.1186/s13195-019-0489-9

Alzheimer's Research & Therapy

Table 1 Volumetry of amygdalar subnuclei, hippocampal subfields, cortical regions and subcortical structures

From: Segmentation of medial temporal subregions reveals early right-sided involvement in semantic variant PPA

			Controls		Early		Middle				Controls		Early		Middle
	Left								Right
	Mean	SD	%	p-value	%	p-value	%	p-value	Mean	SD	%	p-value	%	p-value	%	p-value
Amygdalar Subnuclei
Lateral nucleus
Controls	0.045	0.005							0.047	0.004
Early	0.033	0.010	27	< 0.0005					0.040	0.006	15	0.003
Middle	0.026	0.003	43	< 0.0005	23	< 0.0005			0.035	0.005	25	< 0.0005	12	0.005
Late	0.025	0.003	44	< 0.0005	24	< 0.0005	2	0.723	0.030	0.005	36	< 0.0005	25	< 0.0005	14	0.017
Basal and paralaminar nucleus
Controls	0.033	0.004							0.034	0.003
Early	0.024	0.006	29	< 0.0005					0.029	0.006	15	0.012
Middle	0.018	0.003	46	< 0.0005	24	< 0.0005			0.026	0.004	22	< 0.0005	8	0.092
Late	0.017	0.002	48	< 0.0005	27	< 0.0005	4	0.483	0.021	0.003	39	< 0.0005	29	< 0.0005	22	< 0.0005
Accessory basal nucleus
Controls	0.018	0.002							0.018	0.002
Early	0.012	0.004	32	< 0.0005					0.015	0.004	21	< 0.0005
Middle	0.010	0.002	46	< 0.0005	20	0.002			0.014	0.002	24	< 0.0005	4	0.373
Late	0.009	0.001	49	< 0.0005	25	< 0.0005	6	0.482	0.011	0.002	42	< 0.0005	27	< 0.0005	24	0.002
Cortico-amygdaloid transition area
Controls	0.012	0.002							0.012	0.001
Early	0.009	0.002	24	< 0.0005					0.011	0.003	12	0.157
Middle	0.007	0.001	44	< 0.0005	27	< 0.0005			0.009	0.002	24	< 0.0005	14	0.025
Late	0.006	0.001	48	< 0.0005	32	< 0.0005	7	0.339	0.008	0.002	36	< 0.0005	28	< 0.0005	16	0.049
Superficial nuclei (Ce, Co, Me, AAA)
Controls	0.011	0.002							0.012	0.002
Early	0.007	0.002	35	< 0.0005					0.009	0.002	23	0.004
Middle	0.006	0.001	47	< 0.0005	18	0.005			0.009	0.001	26	< 0.0005	4	0.341
Late	0.005	0.001	51	< 0.0005	25	< 0.0005	9	0.275	0.007	0.002	41	< 0.0005	24	0.002	21	0.024
Hippocampal Subfields
CA1
Controls	0.044	0.005							0.047	0.006
Early	0.035	0.005	22	< 0.0005					0.045	0.008	5	0.995
Middle	0.031	0.007	31	< 0.0005	11	0.020			0.043	0.007	8	0.138	3	0.267
Late	0.029	0.004	36	< 0.0005	18	0.001	7	0.268	0.036	0.006	24	< 0.0005	19	< 0.0005	17	0.003
CA2/CA3
Controls	0.016	0.002							0.017	0.002
Early	0.012	0.002	24	< 0.0005					0.016	0.004	6	0.931
Middle	0.011	0.002	27	< 0.0005	3	0.460			0.015	0.003	12	0.064	7	0.184
Late	0.012	0.002	26	< 0.0005	2	0.518	−1	0.945	0.013	0.002	24	< 0.0005	19	0.002	13	0.054
CA4
Controls	0.018	0.002							0.019	0.002
Early	0.013	0.002	27	< 0.0005					0.017	0.004	10	0.281
Middle	0.013	0.001	27	< 0.0005	1	0.342			0.016	0.002	15	0.003	5	0.156
Late	0.012	0.001	34	< 0.0005	9	0.007	9	0.066	0.015	0.002	21	< 0.0005	13	0.004	8	0.111
Dentate gyrus
Controls	0.021	0.002							0.021	0.002
Early	0.016	0.002	25	< 0.0005					0.020	0.005	7	0.759
Middle	0.015	0.002	27	< 0.0005	4	0.183			0.019	0.003	13	0.021	6	0.132
Late	0.014	0.002	32	< 0.0005	10	0.011	6	0.185	0.017	0.003	19	< 0.0005	14	0.003	8	0.117
Subiculum
Controls	0.028	0.003							0.029	0.003
Early	0.022	0.002	21	< 0.0005					0.028	0.006	1	0.425
Middle	0.020	0.003	28	< 0.0005	10	0.048			0.026	0.005	8	0.116	8	0.074
Late	0.020	0.004	31	< 0.0005	13	0.005	4	0.338	0.022	0.005	23	< 0.0005	23	< 0.0005	16	0.004
Presubiculum
Controls	0.023	0.003							0.022	0.003
Early	0.017	0.002	27	< 0.0005					0.023	0.006	−2	0.173
Middle	0.016	0.002	30	< 0.0005	5	0.362			0.021	0.007	5	0.942	6	0.267
Late	0.016	0.003	33	< 0.0005	8	0.045	3	0.245	0.018	0.005	19	0.001	20	0.001	15	0.015
Hippocampal tail
Controls	0.041	0.005							0.041	0.005
Early	0.034	0.006	18	0.019					0.043	0.010	−4	0.055
Middle	0.030	0.005	28	< 0.0005	12	0.026			0.042	0.010	−2	0.371	2	0.41
Late	0.029	0.006	29	< 0.0005	13	0.009	2	0.624	0.037	0.008	8	0.084	12	0.008	10	0.054
Cortical Regions
Orbitofrontal
Controls	0.697	0.047							0.716	0.048
Early	0.682	0.045	2	0.934					0.727	0.057	−2	0.158
Middle	0.629	0.089	10	0.001	8	0.015			0.716	0.046	0	0.806	1	0.362
Late	0.637	0.063	9	0.009	7	0.062	−1	0.612	0.697	0.078	3	0.647	4	0.166	3	0.604
Prefrontal cortex
Controls	4.216	0.230							4.322	0.224
Early	4.087	0.337	3	0.691					4.299	0.379	1	0.545
Middle	4.045	0.529	4	0.112	1	0.373			4.380	0.369	−1	0.506	−2	0.977
Late	3.806	0.250	10	0.002	7	0.047	6	0.245	4.119	0.269	5	0.201	4	0.168	6	0.153
Anterior cingulate
Controls	0.382	0.039							0.283	0.042
Early	0.315	0.041	18	0.001					0.289	0.046	−2	0.339
Middle	0.300	0.068	22	< 0.0005	5	0.311			0.318	0.069	−13	0.008	−10	0.204
Late	0.255	0.026	33	< 0.0005	19	0.002	15	0.023	0.288	0.058	−2	0.968	0	0.457	9	0.047
Posterior cingulate
Controls	0.359	0.038							0.343	0.035
Early	0.350	0.020	3	0.609					0.368	0.019	−7	0.009
Middle	0.332	0.025	7	0.065	5	0.320			0.365	0.028	−6	0.022	1	0.747
Late	0.337	0.028	6	0.169	4	0.535	−1	0.728	0.361	0.047	−5	0.150	2	0.348	1	0.523
Parietal
Controls	3.224	0.211							3.186	0.229
Early	3.143	0.229	3	0.538					3.216	0.248	−1	0.049
Middle	3.147	0.249	2	0.709	0	0.450			3.272	0.200	−3	0.053	−2	0.944
Late	2.993	0.234	7	0.003	5	0.008	5	0.046	3.142	0.213	1	0.793	2	0.096	4	0.105
Occipital
Controls	2.473	0.207							2.564	0.205
Early	2.393	0.227	3	0.835					2.538	0.195	1	0.575
Middle	2.395	0.155	3	0.552	0	0.776			2.552	0.175	0	0.697	−1	0.887
Late	2.432	0.148	2	0.733	−2	0.926	−2	0.853	2.572	0.147	0	0.796	−1	0.817	−1	0.924
Insula
Controls	0.370	0.035							0.381	0.039
Early	0.281	0.032	24	< 0.0005					0.343	0.049	10	0.110
Middle	0.260	0.036	30	< 0.0005	7	0.064			0.337	0.038	12	0.007	2	0.425
Late	0.229	0.021	38	< 0.0005	18	< 0.0005	12	0.013	0.267	0.039	30	< 0.0005	22	< 0.0005	21	< 0.0005
Medial temporal
Controls	1.012	0.062							1.041	0.067
Early	0.785	0.057	22	< 0.0005					0.981	0.070	6	0.076
Middle	0.730	0.056	28	< 0.0005	7	0.042			0.915	0.070	12	< 0.0005	7	0.044
Late	0.743	0.058	27	< 0.0005	5	0.088	−2	0.787	0.791	0.074	24	< 0.0005	19	< 0.0005	14	< 0.0005
Lateral temporal
Controls	2.304	0.153							2.345	0.143
Early	1.652	0.201	28	< 0.0005					2.231	0.134	5	0.133
Middle	1.554	0.150	33	< 0.0005	6	0.084			2.137	0.099	9	< 0.0005	4	0.105
Late	1.384	0.159	40	< 0.0005	16	< 0.0005	11	0.026	1.864	0.217	21	< 0.0005	16	< 0.0005	13	< 0.0005
Temporal pole
Controls	0.488	0.056							0.477	0.055
Early	0.261	0.066	47	< 0.0005					0.413	0.071	13	0.006
Middle	0.231	0.035	53	< 0.0005	12	0.187			0.352	0.049	26	< 0.0005	15	0.019
Late	0.228	0.029	53	< 0.0005	13	0.324	1	0.766	0.287	0.038	40	< 0.0005	30	< 0.0005	18	0.048
Supratemporal
Controls	0.430	0.050							0.369	0.039
Early	0.348	0.037	19	< 0.0005					0.357	0.045	3	0.910
Middle	0.336	0.046	22	< 0.0005	4	0.359			0.368	0.040	0	0.718	−3	0.855
Late	0.301	0.056	30	<0.0005	14	0.017	10	0.122	0.322	0.054	13	0.004	10	0.028	12	0.016
Subcortical Structures
Nucleus accumbens
Controls	0.040	0.003							0.038	0.003
Early	0.035	0.003	13	<0.0005					0.035	0.003	9	0.048
Middle	0.034	0.005	15	<0.0005	3	0.235			0.036	0.004	5	0.155	−4	0.638
Late	0.030	0.003	24	<0.0005	13	0.001	10	0.019	0.032	0.004	15	<0.0005	7	0.026	11	0.007
Caudate
Controls	0.237	0.026							0.248	0.024
Early	0.221	0.020	7	0.508					0.235	0.026	5	0.598
Middle	0.222	0.026	6	0.350	0	0.851			0.237	0.024	4	0.507	−1	0.929
Late	0.207	0.030	12	0.001	6	0.037	7	0.053	0.217	0.036	12	0.001	8	0.044	8	0.050
Pallidum
Controls	0.129	0.014							0.130	0.013
Early	0.114	0.007	12	0.010					0.119	0.007	8	0.123
Middle	0.113	0.008	12	<0.0005	1	0.160			0.119	0.008	8	0.004	0	0.303
Late	0.104	0.009	19	<0.0005	9	0.016	8	0.270	0.111	0.011	14	<0.0005	6	0.054	7	0.336
Putamen
Controls	0.307	0.031							0.305	0.031
Early	0.268	0.018	13	0.011					0.289	0.016	5	0.981
Middle	0.255	0.023	17	<0.0005	5	0.044			0.277	0.023	9	0.019	4	0.081
Late	0.237	0.018	23	<0.0005	11	0.001	7	0.144	0.261	0.022	14	<0.0005	10	0.002	6	0.142
Thalamus
Controls	0.400	0.035							0.392	0.039
Early	0.357	0.024	11	0.024					0.380	0.032	3	0.279
Middle	0.362	0.029	9	0.008	−2	0.791			0.387	0.036	1	0.258	−2	0.992
Late	0.364	0.027	9	<0.0005	−2	0.169	−1	0.255	0.388	0.027	1	0.226	−2	0.093	0	0.086

Values denote mean and standard deviation (SD) volumes as the percentage of the total intracranial volume (TIV) or difference (%). p values denote significance on linear regression test. Bold represents a significant difference between the groups after correcting for multiple comparisons

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