Table 1 SmartAge study outcome assessment

Enrollment

 Eligibility screening

Telephone

x

 Screening assessment

MMSE [85]

On-site paper

x

x

x

Logical Memory [53]

On-site paper

x

x

x

TMT A [54]

On-site paper

x

x

x

GDS [56, 86]

On-site paper

x

x

x

IADL [55]

On-site paper

x

x

x

 Signed informed consent

On-site

x

 Allocation/randomization

x

Intervention

Assessments

  Demographic information

Age, civil status, education

On-site paper

x

  Family history

Dementia, Parkinson disease, and stroke

On-site paper

x

  Subjective cognitive function

ECog-39 [87]

On-site paper

x

  Lifestyle (lifelong)

LEQ [88]

At-home paper

x

CAI [89]

On-site interview

x

  Personality

BFI-10 [90]

On-site paper

x

SVF-78 [91]

On-site paper

x

  Hand preference

Oldfield Hand Preference [92]

On-site paper

x

  Premorbid IQ

MWT [93]

On-site paper

x

  Genetic markers

APOE ε4 status

On-site

x

  Cerebral PET (optional consent)

Aβ status

On-site

x

  Memory

MST [38]

On-site Computer

x

x

x

  Memory

VLMT [94]

On-site paper

x

x

x

Doors and People [95]

On-site paper

x

x

x

  Executive function

Digit Symbol [96]

On-site paper

x

x

x

TMT B [54]

On-site paper

x

x

x

Block Tapping [97]

On-site paper

x

x

x

Stroop [98]

On-site paper

x

x

x

  Attention

Digit Span [96]

On-site paper

x

x

x

TAP [99] subtests: alertness and divided attention

On-site Computer

x

x

  Language

Semantic/Phonemic Fluency [100]

On-site

x

x

x

Boston Naming Test [100]

On-site paper

x

x

x

   Physical activity

FKA [101]

At-home paper

x

x

x

   Cognitive activity

CAI Present [89]

On-site interview

x

x

x

   Sleep quality

PSQI [102]

At-home paper

x

x

x

   Diet

FFQ [33, 63]

At-home paper

x

x

x

MEDAS [103, 104]

On-site paper

x

x

x

FFL [19, 62]

At-home paper

x

x

x

  Psycho-affective/worry

PSWQ [105, 106]

At-home paper

x

x

x

RSQ-D [107]

On-site paper

x

x

x

STAI-G [108]

On-site paper

x

x

x

  Quality of life

SF-12 [109]

On-site paper

x

x

x

WHOQOL-BREF [110]

At-home paper

x

x

x

  Autophagy markers from muscle biopsy (optional consent)

LC3 I/II, p62 [72], EP300 [111], proteomics, metabolomics [73]

On-site

x

x

  Blood-based markers

Polyamine levels [33], metabolomics, proinflammatory biomarkers, and neurotrophin levels

On-site

x

x

  Cerebral neuroimaging markers

Brain structure, perfusion, function

On-site

x

x

  Subjective cognitive function

ECog-39, adapted [87]

On-site paper

x

x

x

MMQ, adapted [112]

On-site paper

x

x

x

  Cardiovascular risk factors

Blood pressure, lipid profile, glucose metabolism

On-site

x

x

x

  Muscle function/strength*

SPPB [113]

On-site

x

x

x

Handgrip strength

On-site

x

x

x