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Table 4 Performance to predict progression for clinicians without and with the PredictND tool, and the DSI classification alone

From: Impact of a clinical decision support tool on prediction of progression in early-stage dementia: a prospective validation study

Cohort

SN

SP

PPV

NPV

Accuracy

Bal. Acc.

All (n = 429)

 Without tool

0.67

0.79

0.43

0.91

0.76

0.73

 With tool

0.60

0.81

0.43

0.89

0.77

0.70

 DSI

0.63

0.83

0.47

0.90

0.79

0.73

Excl. non-AD dementia (n = 405)

 Without tool

0.67

0.79

0.35

0.93

0.77

0.73

 With tool

0.62

0.81

0.36

0.92

0.78

0.71

 DSI

0.63

0.83

0.39

0.93

0.80

0.73

SCD (n = 230)

 Without tool

0.67

0.87

0.34

0.96

0.85

0.77

 With tool

0.67

0.88

0.35

0.96

0.86

0.77

 DSI*

0.33

0.96

0.47

0.93

0.90

0.65

MCI (n = 199)

 Without tool

0.67

0.66

0.48

0.81

0.66

0.66

 With tool

0.57

0.71

0.48

0.78

0.67

0.64

 DSI

0.73

0.62

0.47

0.83

0.65

0.67

DSI ≤ 0.2 or DSI ≥ 0.8 (n = 203)

 Without tool

0.67

0.92

0.44

0.97

0.90

0.79

 With tool

0.61

0.96

0.58

0.96

0.93

0.78

 DSI

0.78

0.98

0.78

0.98

0.96*

0.88

  1. Abbreviations: Prog conversion of SCD to MCI, AD or another type of dementia, and MCI to AD or another type of dementia; SN sensitivity; SP specificity; PPV positive predictive value; NPV negative predictive value; Bal.Acc. balanced accuracy; DSI disease state index; SCD subjective cognitive decline; MCI mild cognitive impairment
  2. **Significant difference between without tool and DSI classification accuracy, p = 0.012
  3. *Results from different cutoff values are available in Additional file 1: Table S8