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Table 4 Predictors of death and institution over the follow-up, multivariable Cox regression analyses

From: CSF level of β-amyloid peptide predicts mortality in Alzheimer’s disease

Characteristics

Death

Institutionalization

HR (95% CI)

P value

HR (95% CI)

P value

Age, yeara

1.66 (1.21–2.28)

0.002

1.11 (0.86–1.44)

0.44

Men vs women

2.11 (1.19–3.76)

0.01

1.56 (0.94–2.59)

0.09

Level of educationb

 Low

Ref.

Ref.

 Intermediate

1.21 (0.58–2.52)

0.61

2.45 (1.25–4.83)

0.009

 High

1.02 (0.45–2.31)

0.96

1.45 (0.68–3.09)

0.33

MMSE scorec

1.56 (1.16–2.10)

0.003

1.68 (1.29–2.18)

< 0.001

APOE ε4 allele

 0

Ref.

Ref.

 1

0.79 (0.43–1.44)

0.44

1.00 (0.58–1.73)

0.98

 2

0.59 (0.25–1.36)

0.21

0.70 (0.32–1.52)

0.37

Collection tube, before 2012 vs recent

1.37 (0.60–3.01)

0.46

0.74 (0.36–1.52)

0.41

CSF Aβ42, pg/mLc

1.89 (1.25–2.86)

0.002

0.89 (0.60–1.32)

0.55

CSF tau, pg/mLa

1.11 (0.84–1.48)

0.45

0.99 (0.78–1.26)

0.96

  1. aContinuous, estimate for 1 standard deviation increase
  2. bLow: primary school or less, intermediate: secondary to high school, high: baccalaureate or university degree
  3. cContinuous, estimate for 1 standard deviation decrease