Table 1 Demographics and characteristics of CSF biomarkers and PET quantification measures, overall and by cohort. All the characteristics shown in this table were statistically different (p < 0.001) between cohorts
From: Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers
ALL (n = 516) | ALFA+ (n = 205) | ADNI (n = 311) | |
|---|---|---|---|
Age, mean (SD) [range] | 69.13 (9.10) [50–92] | 61.01 (4.85) [50–74] | 74.48 (7.07) [56–92] |
Women, n (%) | 286 (55.4) | 134 (65.4) | 152 (48.9) |
Education, years mean (SD) | 14.98 (3.37) | 13.49 (3.58) | 15.96 (2.82) |
APOE-ε4 carriers, n (%) | 260 (50.4) | 81 (39.5) | 179 (57.6) |
Positive Aβ42, n (%) | 273 (52.9) | 60 (29.3) | 213 (68.5) |
Positive pTau, n (%) | 323 (62.6) | 56 (27.3) | 267 (85.9) |
Positive tTau, n (%) | 294 (57.0) | 50 (24.4) | 244 (78.5) |
Positive pTau/Aβ42, n (%) | 258 (50.0) | 24 (11.7) | 234 (75.2) |
Positive tTau/Aβ42, n (%) | 246 (47.7) | 21 (10.2) | 225 (72.3) |
Diagnostic, n (%) CN/MCI/AD | 256 / 237 / 23 (49.6)/(45.9)/(4.5) | 205 / 0 / 0 (100)/(0)/(0) | 36 / 237 / 23 (11.6)/(76.2)/(7.4) |
Time difference CSF-PET, days mean (SD) [range] | 45.2 (60.3) [0–343] | 97.1 (65.1) [14–343] | 11.0 (17.2) [0–126] |