From: Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer’s disease
Dementia | No dementia | |
---|---|---|
n | 7 | 24 |
Age (years) | 52.00 ± 10.36 (40–67) | 45.25 ± 10.90 (23–65) |
Sex | 2 (28.6%) females, 5 (71.4%) males | 7 (29.2%) females, 17 (70.8%) males |
Intellectual disability severitya | 5 (71.4%) mild, 1 (14.3%) moderate, 1 (14.3%) severe | 12 (50.0%) mild, 10 (41.7%) moderate, 2 (8.3%) severe |
APOE ε4 carrier | 4 (57.1%) carriers, 3 (42.9%) non-carriers | 4 (16.7%) carriers, 20 (83.3%) non-carriers |
Aβ40 | 320.80 (268.20–555.00) | 304.80 (150.24–528.00) |
Aβ42 | 26.36 (15.16–42.40) | 24.14 (14.92–50.40) |
Aβ42/Aβ40 | 0.08 (0.05–0.09) | 0.09 (0.05–0.13) |
Aβ42/t-tau | 14.76 (2.73–29.18) | 20.86 (1.17–93.33) |
T-tau | 1.88 (0.99–8.96) | 1.27 (0.18–12.72) |
IL1βb | 3.79 (1.65–5.10) | 1.44 (0.27–47.20) |
IL10c | 1.78 (0.62–6.33) | 1.26 (0.36–93.20) |
IL6c | 2.12 (0.44–58.40) | 2.12 (0.36–1024.00) |
TNFαc | 2.58 (1.25–29.84) | 3.08 (1.30–328.80) |
NfLd | 59.84 (16.36–112.60) | 25.10 (10.97–55.45) |