Table 2 Concentrations of biomarkers for each group and group comparisons
From: Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer’s disease
DS | sAD | Controls | ANCOVA | Post hoc | |
|---|---|---|---|---|---|
Aβ40 | 312.00 (150.24–555.00) | 160.80 (43.60–420.00) | 144.40 (26.88–355.60) | F(2,79) = 24.28, p < 0.001, η2 = 0.38 | DS vs sAD p < 0.001 DS vs controls p < 0.001 sAD vs controls p = 0.506 |
Aβ42 | 24.48 (14.92–50.40) | 13.32 (4.28–18.84) | 14.76 (2.00–45.62) | F(2,79) = 20.36, p < 0.001, η2 = 0.34 | DS vs sAD p < 0.001 DS vs controls p < 0.001 sAD vs controls p = 0.710 |
Aβ42/Aβ40 | 0.09 (0.05–0.13) | 0.08 (0.04–0.11) | 0.10 (0.07–0.17) | F(2,79) = 15.43, p < 0.001, η2 = 0.28 | DS vs sAD p = 1.000 DS vs controls p < 0.001 sAD vs controls p < 0.001 |
Aβ42/t-tau | 20.60 (1.17–93.33) | 10.23 (0.77–52.00) | 10.59 (1.14–82.25) | F(2,79) = 2.30, p = 0.107, η2 = 0.06 | N/A |
T-tau | 1.45 (0.18–12.72) | 1.00 (0.33–24.48) | 1.49 (0.16–10.24) | F(2,79) = 0.64, p = 0.529, η2 = 0.02 | N/A |
IL1βa | 2.35 (0.27–47.20) | 0.18 (0.02–5.45) | 0.09 (0.00–1.25) | F(2,41) = 13.84, p < 0.001, η2 = 0.40 | DS vs sAD p = 0.002 DS vs controls p < 0.001 sAD vs controls p = 1.000 |
IL10b | 1.34 (0.36–93.20) | 0.75 (0.27–8.76) | 0.87 (0.27–4.48) | F(2,76) = 2.38, p = 0.100, η2 = 0.06 | N/A |
IL6b | 2.12 (0.36–1024.00) | 1.45 (0.50–9.56) | 1.54 (0.07–8.70) | F(2,76) = 2.54, p = 0.086, η2 = 0.06 | N/A |
TNFαb | 2.76 (1.25–328.80) | 2.37 (1.36–20.44) | 1.97 (0.56–10.50) | F(2,76) = 2.42, p = 0.096, η2 = 0.06 | N/A |