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Table 2 Distribution of the NRXN3 rs8019381 C/T SNP and APOE allele frequencies among the rs8019381 genotypes

From: Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer’s disease

Group

Genotypea

Allele frequency

P value

CC

CT

TT

C

T

rs8019381 genotype and allele frequenciesb

 Control (n = 336)

291 (0.866)

43 (0.128)

2 (0.006)

0.930

0.070

Genotype: P = 0.00041 (X2 = 15.6, df = 2)

Allele: P = 0.000063 (X2 = 16.0, df = 1)

 AD (n = 121)

86 (0.711)

32 (0.264)

3 (0.025)

0.843

0.157

rs8019381 genotypes among APOE ε4 non-carriers and APOE ε4 carriers

 Control

APOE ε4 non-carriers

216 (0.857)

35 (0.139)

1 (0.004)

0.927

0.073

APOE ε4 non-carriers VS.ε4 carriers in the AD

Genotype: P = 0.018 (X2 = 8.0, df = 2)

Allele: P = 0.000063 (X2 = 0.43, df = 1)

APOE ε4 carriers

75 (0.893)

8 (0.095)

1 (0.012)

0.940

0.060

 AD

APOE ε4 non-carriers

26 (0.722)

7 (0.195)

3 (0.083)

0.819

0.181

APOE ε4 carriers

60 (0.706)

25 (0.294)

0 (0.000)

0.853

0.147

  1. aNumber of subjects (frequency)
  2. brs8019381: Significant differences were found between the AD and the controls in either the genotype distribution (χ2 = 15.587, df = 2, P = 0.000413) or the allele frequencies (χ2 = 15.997, df = 1, P = 0.0000634)