Skip to main content

Table 2 18F-flortaucipir standardized uptake value ratio in various regions of interest (for CBS, left is contralateral to symptom onset)

From: 18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes

  

CMF

RMF

SF

OF

IN

PO

PT

PC

TL

TP

WM

CMF

Left or CL

 Controls n = 53

Mean ± sd

1.06 ± 0.1

1.06 ± 0.1

1.03 ± 0.1

1.16 ± 0.1

1.11 ± 0.12

1.06 ± 0.09

1.09 ± 0.1

1.01 ± 0.09

1.14 ± 0.09

1.12 ± 0.1

1.2 ± 0.16

[min, max]

[0.81,1.3]

[0.84,1.26]

[0.79,1.25]

[0.79,1.33]

[0.78,1.37]

[0.82,1.3]

[0.86,1.3]

[0.78,1.2]

[0.88,1.28]

[0.8,1.29]

[0.82,1.6]

 nfvPPA n = 11

Mean ± sd

1.15 ± 0.09

1.09 ± 0.05

1.09 ± 0.05

1.2 ± 0.05

1.13 ± 0.05

1.19 ± 0.07

1.18 ± 0.05

1.08 ± 0.04

1.15 ± 0.05

1.14 ± 0.09

 

[min, max]

[1,1.37]

[1.02,1.19]

[1.-3.1.18]

[1.1,1.26]

[1.05,1.24]

[1.1,1.35]

[1.12,1.26]

[1.02,0.16]

[1.08,1.24]

[0.97,1.31]

n/a

p value

0.01

0.22

0.0306

0.19

0.84

0.0001

0.0016

0.003

0.88

0.53

 

 CBS n = 7

Mean ± sd

1.05 ± 0.09

1.02 ± 0.06

1.01 ± 0.07

1.18 ± 0.06

1.11 ± 0.08

1.1 ± 0.08

1.12 ± 0.06

1.06 ± 0.07

1.15 ± 0.04

1.08 ± 0.06

1.29 ± 0.14

[min, max]

[0.95,1.19]

[0.93,1.08]

[0.91,1.11]

[1.09,1.16]

[1.04,1.28]

[1,1.26]

[1.05,1.2]

[0.96,1.13]

[1.07,1.2]

[0.99,1.16]

[1.41,1.56]

p value

0.59

0.29

0.44

0.65

0.77

0.44

0.36

0.09

0.79

0.38

0.33

 MAPT n = 6

Mean ± sd

1.11 ± 0.33

1.07 ± 0.12

1.02 ± 0.27

1.22 ± 0.1

1.21 ± 0.1

1.14 ± 0.19

1.12 ± 0.13

0.96 ± 0.2

1.21 ± 0.1

1.4 ± 0.35

 

[min, max]

[0.64,1.56]

[0.9,1.21]

[0.59,1.35]

[1.1,1.4]

[1.1,1.32]

[0.88,1.37]

[0.98,1.29]

[0.58,1.12]

[1.11,1.33]

[1.13,2.01]

n/a

p value

0.92

0.71

0.96

0.26

0.048

0.22

0.45

0.98

0.15

0.015

 

 bvFTD n = 10

Mean ± sd

1.05 ± 0.15

1.03 ± 0.14

1.01 ± 0.14

1.14 ± 0.17

1.05 ± 0.15

1.05 ± 0.14

1.08 ± 0.16

0.97 ± 0.13

1.12 ± 0.12

1.13 ± 0.13

 

[min, max]

[0.8,1.21]

[0.81,1.23]

[0.8,1.23]

[0.88,1.38]

[0.78,1.25]

[0.81,1.3]

[0.84,1.41]

[0.77,1.2]

[0.91,1.29]

[0.85,1.3]

n/a

p value

0.98

0.48

0.71

0.71

0.25

0.64

0.32

0.35

0.84

0.62

 

 C9ORF72 & PGRN

n = 6

Mean ± sd

1.08 ± 0.16

1.08 ± 0.13

1.02 ± 0.16

1.25 ± 0.1

1.12 ± 0.06

1.14 ± 0.1

1.22 ± 0.15

1.01 ± 0.11

1.18 ± 0.09

1.2 ± 0.16

 

[min, max]

[0.96,1.39]

[0.95,1.3]

[0.92,1.31]

[1.12,1.41]

[1.06,1.21]

[1.06,1.34]

[1.01,1.44]

[0.91,1.22]

[1.07,1.32]

[1.05,1.46]

n/a

p value

0.65

0.98

0.28

0.06

0.96

0.08

0.039

0.65

0.24

0.27

 

 svPPA n = 2

Mean ± sd

1 ± 0.11

1.05 ± 0.04

1 ± 0.01

1.2 ± 0.07

1.18 ± 0.07

1.09 ± 0.07

1.11 ± 0.04

0.98 ± 0.08

1.23 ± 0.03

1.43 ± 0.07

 

[min, max]

[0.92,1.08]

[1.03,1.08]

[0.99,1.01]

[1.15,1.25]

[1.13,1.23]

[1.04,1.14]

[1.08,1.15]

[0.92,1.04]

[1.21,1.25]

[1.38,1.47]

n/a

p value

0.39

0.92

0.53

0.56

0.39

0.65

0.72

0.62

0.09

0.017

 

Right or IL

 Controls n = 53

Mean ± sd

1.05 ± 0.1

1.05 ± 0.1

1.04 ± 0.1

1.17 ± 0.1

1.12 ± 0.12

1.07 ± 0.09

1.1 ± 0.09

1.01 ± 0.09

1.14 ± 0.09

1.13 ± 0.1

1.2 ± 0.16

[min, max]

[0.78,1.28]

[0.83,1.23]

[0.79,1.28]

[0.78,1.35]

[0.8,1.42]

[0.81,1.28]

[0.85,1.24]

[0.78,1.17]

[0.88,1.27]

[0.88,1.41]

[0.8,1.58]

 nfvPPA n = 11

Mean ± sd

1.1 ± 0.06

1.1 ± 0.04

1.08 ± 0.04

1.2 ± 0.06

1.12 ± 0.05

1.15 ± 0.04

1.18 ± 0.07

1.08 ± 0.05

1.15 ± 0.05

1.11 ± 0.07

 

[min, max]

[1.01,1.17]

[1.01,1.16]

[1.03,1.16]

[1.12,1.34]

[1.05,1.24]

[1.1,1.23]

[1.09,1.34]

[1,1.17]

[1.1,1.29]

[1,1.25]

n/a

p value

0.06

0.13

0.0453

0.37

0.85

0.0018

0.0029

0.0112

0.96

0.22

 

 CBS n = 7

Mean ± sd

1.04 ± 0.08

1.01 ± 0.06

0.98 ± 0.05

1.18 ± 0.06

1.13 ± 0.04

1.08 ± 0.05

1.1 ± 0.09

1.04 ± 0.05

1.16 ± 0.06

1.08 ± 0.04

1.24 ± 0.1

[min, max]

[0.94,1.18]

[0.92,1.07]

[0.91,1.04]

[1.06,1.25]

[1.01,1.14]

[1.01,1.14]

[0.97,1.19]

[0.95,1.07]

[1.06,1.22]

[1.02,1.13]

[1.12,1.41]

p value

0.67

0.16

0.049

0.81

0.95

0.88

0.76

0.26

0.48

0.08

0.54

 MAPT n = 6

Mean ± sd

1.09 ± 0.35

1.08 ± 0.15

1.02 ± 0.25

1.21 ± 0.1

1.21 ± 0.12

1.14 ± 0.19

1.13 ± 0.15

0.95 ± 0.17

1.21 ± 0.08

1.36 ± 0.35

 

[min, max]

[0.56,1.49]

[0.91,1.33]

[0.61,1.34]

[1.1,1.32]

[1.09,1.36]

[0.88,1.42]

[0.9,1.35]

[0.62,1.1]

[1.12,1.32]

[1.1,2.05]

n/a

p value

0.76

0.82

0.92

0.48

0.15

0.39

0.53

0.73

0.1

0.035

 

 bvFTD n = 10

Mean ± sd

1.02 ± 0.12

1.03 ± 0.14

0.98 ± 0.13

1.12 ± 0.13

1.05 ± 0.14

1.05 ± 0.15

1.09 ± 0.14

0.96 ± 0.12

1.11 ± 0.1

1.05 ± 0.07

 

[min, max]

[0.79,1.18]

[0.81,1.2]

0.77,1.14

[0.9,1.31]

[0.79,1.24]

[0.77,1.31]

[0.84,1.31]

[0.76,1.14]

[0.92,1.22]

[0.96,1.15]

n/a

p value

0.61

0.69

0.19

0.28

0.17

0.76

0.51

0.32

0.55

0.007

 

 C9ORF72 & PGRN n = 6

Mean ± sd

1.06 ± 0.2

1.08 ± 0.14

1.02 ± 0.16

1.26 ± 0.08

1.15 ± 0.09

1.16 ± 0.1

1.23 ± 0.15

1.02 ± 0.11

1.19 ± 0.08

1.17 ± 0.09

 

[min, max]

[0.92,1.44]

[0.98,1.31]

[0.91,1.32]

[1.17,1.38]

[1.03,1.24]

[1.08,1.35]

[1.08,1.45]

[0.94,1.24]

[1.08,1.27]

[1.08,1.29]

n/a

p value

0.46

0.96

0.21

0.042

0.54

0.045

0.037

0.88

0.21

0.62

 

 svPPA n = 2

Mean ± sd

1.03 ± 0.08

1.07 ± 0.01

1 ± 0.1

1.17 ± 0.1

1.13 ± 0.09

1.12 ± 0.08

1.12 ± 0.07

1 ± 0.1

1.16 ± 0.1

1.21 ± 0.05

 

[min, max]

[0.97,1.09]

[1.07,1.08]

[0.99,1.01]

[1.1,1.24]

[1.07,1.19]

[1.06,1.17]

[1.07,1.18]

[0.93,1.07]

[1.09,1.22]

[1.18,1.24]

n/a

p value

0.65

0.75

0.42

0.93

0.96

0.39

0.82

0.89

1

0.15

 
  1. CL contralateral so symptom onset for CBS group, CMF caudal middle frontal, RMF rostral middle frontal, SF superior frontal, OFL orbitofrontal, IF inferior frontal, IN insula, PO pars opercularis, PT pars triagularis, PC precentral, TL temporal lobe, TP temporal pole, WMCMF white matter caudal middle frontal, IL ipsilateral to symptom onset for CBS group
  2. ROIs with significantly elevated signal compared to controls (p < 0.05) are italicized
Back to article page

Alzheimer's Research & Therapy

ISSN: 1758-9193